目的:比较双导丝聚力球囊与普通球囊在直径≤2.5 mm小血管病变介入治疗中的即刻效果及远期预后.方法:连续入选冠状动脉(冠脉)造影显示小血管病变(参考血管直径≤2.5 mm)需行介入治疗的患者,连续入选的150例小血管病变患者随机分成试验组75例,对照组75例.试验组:双导丝聚力球囊单纯扩张;对照组:普通球囊单纯扩张.观察介入治疗即刻成功率、血管并发症发生率.6~9个月时复查冠脉造影,观察小血管病变再狭窄发生率.观察12个月内小血管病变相关的心脏不良事件(MACE).结果:采用双导丝聚力球囊对小血管病变进行介入治疗手术试验组成功率97.3%,对照组86.7%(P=0.015),术中并发症发生率两组分别为1.3%与6.7%(P=0.032).6~9个月复查冠脉造影,试验组与对照组靶病变再狭窄发生率分别为12.7%与31.8%(P<0.05),12个月与小血管病变相关的MACE发生率两组分别为5.4%及18.5%(P=0.035),差异均有统计学意义.结论:双导丝聚力球囊与普通球囊相比,可降低小血管病变手术并发症,提高手术成功率,降低1年内靶病变再狭窄及MACE发生率.是小血管病变介入治疗又一可选择的介入治疗方法.%Objective:To compare the immediate and long term effect between dual-wire focused force angioplasty and balloon angiopla-sty for treating small coronary artery lesions.rnMethods:A total of 150 consecutive patients with coronary angiography( CAG )confirmed lesions in small coronary arteries in diameter≤2. 5 mm were randomly assigned into 2 groups. Group A,the patients received dual-wire focused force angioplasty and Group B,the patients had balloon angioplasty group. n = 75 in each group. Follow-up CAG performed 6 ～9 months after the treatment to observe the vessel restenosis and major adverse cardiac event( MACE )related to small vessel lesions.rnResults:Procedural success rate in Group A and Group B was 97. 3% vs. 86.7% ,P = 0.015, the procedural complication was 1. 3% vs. 6. 7% ,P=0. 032. The follow-up CAG indicated that the vessel restenosis in Group A and Group B was 12. 7% vs. 31. 8% ,P< 0. 05,the occurrence of MACE at 12 months was 5. 4% vs. 18. 5% ,P = 0. 035.rnConclusion: Compared with balloon angioplasty, dual-wire focused force angioplasty could reduce the procedural complications and increase the success rate for small coronary artery disease intervention; it also had less retenosis and MACE within 1 year of treatment.
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