L型钙通道阻滞剂和康复运动对冠心病患者血压和血脂状况的影响

摘要

Objective :To examine effect of L‐type calcium channel blocker and exercise training management on blood pressure and blood lipids status of coronary heart disease patients .Meth‐ods :Thirty female coronary heart disease patients were recruited as subjects in the study . Then ,according to with or without L‐type calcium channel blockers management ,they were subdivided into two groups ,i .e .medication group (n= 13 ) and non‐medication group (n=17) .After that ,values of systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,heart rate (HR) ,rate‐pressure product (RPP) ,and total (CHO) ,low‐density lipoprotein (LDL) , high‐density lipoprotein (HDL ) cholesterol levels and data on triglyceride (TG ) were obtained from the patients both pre and post a 12‐week exercise based rehabilitation program .Results :1) Effects of medication :The medication group showed a similar level of blood pressure to the non‐medication group ( P> 0 .05 ) pre the exercise training program ,but its HR was signifi‐cantly lower than that of the non‐medication group ( P< 0 .05 ) .There was a non significant difference between the two groups for values of any blood lipids variables ( P> 0 .05 ) .2 ) Effects of exercise training :Compared with pre program ,values of SBP ,HR ,RPP and CHO showed a significant decrease in non‐medication group post the program ( P< 0 .05 and P<0 .01) .3) Combined effects of medication and exercise training :Compared with pre program , blood lipids status ,not only CHO but also TG and HDL levels improved significantly in medi‐cation group post the program(P<0 .05) .Conclusion :Optimal exercise training demonstrated a positive effect on blood pressure ,blood lipids and myocardial oxygen consumption status im‐proving in coronary heart disease patients .Compared with exercise alone ,L‐type calcium chan‐nel blocker plus exercise training management provided more benefits for blood lipids modifying in the patients .%目的：探讨L型钙通道阻滞剂和康复运动对冠心病患者血压和血脂状况的影响。方法：13名服用L型钙通道阻滞剂的女性冠心病患者（服药组），17名不服用 L型钙通道阻滞剂的女性冠心病患者（未服药组）为本研究的受试者，在康复程序前、后，对她们进行了收缩压（SBP）、舒张压（DBP）、心率（HR）、心率血压乘积（RPP）、血清胆固醇（CHO）、甘油三酯（TG ）、高密度脂蛋白胆固醇（HDL ）和低密度脂蛋白胆固醇（LDL ）的测定。结果：1）药物的影响：运动康复程序前，服药组的收缩压和舒张压与未服药组已无显著差异（P＞0．05），但其心率显著低于未服药组（P＜0．05），两组血脂各项指标间无显著差异的存在（P＞0．05）。2）运动的影响：运动康复程序后，未服药组的SBP、HR、RPP和 CHO出现了显著的下降（ P＜0．05和 P＜0．01）。3）药物与运动的共同影响：运动康复程序后，服药组不仅胆固醇浓度显著下降（ P＜0．05），而且 TG和 HDL也有了显著的改善（ P＜0．05）。结论：适宜的运动对改善冠心病患者的血压、血脂和心肌的耗氧状况有积极的作用；与单纯运动相比，L 型钙通道阻滞剂与运动的共同作用对血脂的影响则更为明显。