静脉胺碘酮转复阵发性房颤临床疗效观察

摘要

目的：观察应用静脉胺碘酮转复阵发性房颤的有效性及安全性。方法选择本科阵发性房颤38例，给予胺碘酮150 mg＋5％GS 20 ml于15 min内缓慢静脉推注，观察20 min，房颤未转复，继续给予胺碘酮1 mg/min持续泵入，6 h后减为0.5 mg/min维持72 h。结果38例复律成功32例，1/2 h内转复者5例，1/2 h～24 h内转复者14例，24 h～48 h转复者9例，48 h～72 h转复者4例，总成功率84.2％。未发现明显不良反应。结论静脉胺碘酮转复阵发性房颤具有较好的疗效和安全性，并且不良反应轻。%Objective To observe the efficacy and safety of using intravenous amiodarone for the card-ioversion of paroxysmal atrial fibrillation .Methods 38 cases with paroxysmal atrial fibrillation were injected with loaded amiodarone (150 mg within 15 min), the cases failed within half an hour followed by a dose of 1 mg/min maintained for 6 h,then 0.5 mg/min maintained for 72 h.Results 32 cases reverted to sinus rhythm , five cases within the first 20 min, fourteen during 1/2 h~24 h, nine during 24 h~48 h,four during 48 h~72 h.The conversion rate was 84.2%.No adverse effects occurred .Conclusion It is effective and safe with in-travenous amiodarone in treatment of paroxysmal atrial fibrillation .