维持性血液透析并高血压患者餐前餐后服用降压药效果分析

摘要

Objective To observe the curative effect of maintenance hemodialysis combined with hypotensive drugs administration before and after meal in hypertension patients, in order to provide appropriate method for treatment. Methods A total of 100 maintenance hemodialysis combined with hypertension patients were randomly divided into two groups. Pre-meal group received 5~10 mg/d of amlodipine tablets before breakfast once a day with 1 captopril tablet 3 times a day before each meal. Post-meal group received 5~10 mg/d of amlodipine tablets after breakfast once a day with 1 captopril tablet 3 times a day after each meal. Treatment lasted for 6 months in both groups. Results After treatment, the total effective rate was higher in the pre-meal group (88.00%) than the post-meal group (68.00%). Their difference had statistical significance (P<0.05). Compared with blood pressure changes in the post-meal group, the pre-meal group had more decrease in systolic pressure, and their difference had statistical significance (P<0.05). Conclusion Administration of hypotensive drugs before meal can effectively control blood pressure in maintenance hemodialysis combined with hypertension patients, and this method should be widely applied in clinic.%目的：观察维持性血液透析并高血压患者餐前餐后服用降压药的治疗效果,为此类病的治疗寻找更合适的方法。方法100例维持性血液透析并高血压患者,按随机原则分成两组。餐前组的患者早餐前服用5~10 mg/d 的氨氯地平片,1次/d,同时每顿餐前服用1片卡托普利,3次/d。餐后组的患者早餐后服用5~10 mg/d 的氨氯地平片,1次/d,同时每顿餐后服用1片卡托普利,3次/d。两组患者进行治疗的时间都为6个月。结果治疗后,两组的治疗总有效率对比,餐前组(88.00%)比餐后组(68.00%)高,差异有统计学意义(P<0.05)。同时,与餐后组患者的血压变化情况对比,餐前组的收缩压下降的较多(P<0.05)。结论维持性血液透析并高血压患者在餐前服用降压药后,血压能够得到较好的控制,应该在临床中多加运用。