替罗非班在急性心肌梗死急诊介入治疗不同使用时间对冠脉血流及近期预后疗效的对比分析

摘要

Objective To comparatively analyze the effect of different application time of tirofiban in emergent interventional treatment of acute myocardial infarction on coronary blood flow and recent prognosis. Methods A total of 58 acute myocardial infarction patients were randomly divided into tirofiban early use group (early group) and late use group (late group), with 29 cases in each group. The two groups received tirofiban at different time period. The curative effects of the two groups were compared. Results The early group’s TIMI frames was significantly lower than that of the late group (P<0.05). The early group’s Blush 3 level was significantly higher than that of the late group (P<0.01), and its peak concentration of creatine kinase was also significantly lower than the late group (P<0.05). The early group had larger ST decline in the postoperative 90 min than the late group (P<0.05). Conclusion Application of tirofiban during emergency surgery for acute myocardial infarction patients has good curative effect and high safety. It can improve coronary blood flow in early use, and provide significant effect in recent prognosis.%目的：对比分析替罗非班在急性心肌梗死急诊介入治疗不同使用时间对冠脉血流及近期预后的疗效。方法58例急性心肌梗死患者，随机分为替罗非班早期使用组(早期组)和晚期使用组(晚期组)，每组29例。两组患者在治疗的不同时期介入使用替罗非班，比较分析两组患者的治疗效果。结果早期组的TIMI帧数明显的低于晚期组(P<0.05)；早期组Blush的3级率显著高于晚期组(P<0.01)，肌酸激酶的峰值浓度也明显低于晚期组(P<0.05)；早期组在术后的90 min ST下降幅度也大于晚期组(P<0.05)。结论在急性心肌梗死患者的急诊手术中使用替罗非班具有良好的治疗效果，且十分安全，在早期使用能改善冠脉血流，在近期预后中也有着显著疗效。