204例儿童感染鼠伤寒沙门氏菌临床分析

摘要

Objective To retrospectively analyze drug resistance of children infected mouse typhus salmonella, and to guide rational clinical drug use.Methods Salmonella from 420 children with salmonella diarrhea were separated from faeces, and their serum type was confirmed by serology agglutination test. Kerby-Bauer disk diffusion test was used to detect sensitivity to antibacterial agents.Results Among 420 separated salmonella from faeces, there were 204 mouse typhus salmonella cases, accounting for 48.57%, which was resistant to multiple antibiotics. It showed complete resistance to sulfonamides (100.0%), followed by ampicillin (93.6%), streptomycin (94.1%) and tetracycline (98.0%) with high resistance rates. Ceftazidime (2.0%) and ciprofloxacin (2.0%) had the lowest resistance rates, and others showed various resistance.Conclusion Mouse typhus salmonella shows resistance for various antibiotics, along with multi-drug resistance. Rational application of antibiotics is necessary in accordance with drug sensitivity outcomes.%目的：回顾分析临床儿童感染鼠伤寒沙门氏菌耐药情况，指导临床合理用药。方法420例沙门氏菌腹泻儿童，从其粪便中分离沙门氏菌，采用血清学凝集试验确定沙门氏菌血清型，再采用Kerby-Bauer纸片扩散法检测其对抗菌药物的敏感性。结果从腹泻儿童粪便分离出420例沙门氏菌中，鼠伤寒沙门氏菌204例，占48.57%。鼠伤寒沙门氏菌对多种抗生素产生耐药，对磺胺类药全部耐药(100.0%)，耐药率较高的还有氨苄西林(93.6%)，链霉素(94.1%)，四环素(98.0%)；耐药率最低的是头孢他啶(2.0%)，环丙沙星(2.0%)，其余出现不同程度的耐药性。结论鼠伤寒沙门氏菌对多种抗生素产生耐药性，并出现多重耐药性，临床上需根据药敏结果合理使用抗生素。