乙型肝炎病毒感染与弥漫大B细胞淋巴瘤临床病理的关系

摘要

ObjectiveTo investigate clinicopathologic relationship between hepatitis B virus infection and diffuse large B cell lymphoma.MethodsEnzyme linked immunosorbent assay was applied in 200 patients with diffuse large B cell lymphoma in initial treatment, and they were divided by hepatitis B surface antigen detection. Detected outcomes of the two groups were compared and analyzed.ResultsDetection showed 46 cases in positive hepatitis B surface antigen group and 154 cases in negative hepatitis B surface antigen group. Differences of age, stage, liver injury before and after chemotherapy, incidence of hepatitis, and activation rate between the two groups all had statistical significance (P<0.05).ConclusionDiffuse large B cell lymphoma patients show higher positive hepatitis B surface antigen rate than normal people, thus there is certain relationship between hepatitis B virus infection and diffuse large B cell lymphoma. It requires further clinical research and improvement.%目的：探讨乙型肝炎病毒感染与弥漫大B细胞淋巴瘤临床病理的关系。方法200例初治弥漫大B细胞淋巴瘤患者，采用酶联免疫吸附试验检测其肝功能，根据乙型肝炎表面抗原检测结果的阴阳性进行分组，对比分析两组的检测结果。结果经检测，乙型肝炎表面抗原阳性组46例，乙型肝炎表面抗原阴性组154例，两组年龄、分期、化疗前后肝损伤情况、肝炎发生率、激活率比较，差异均具有统计学意义(P<0.05)。结论弥漫大B细胞淋巴瘤患者的乙型肝炎表面抗原阳性率较普通人高，乙型肝炎病毒感染的发生与弥漫大B细胞淋巴瘤有一定的关系，需要临床医学更深入的研究和完善。