塑料输液瓶和输液器对地西泮的吸附性考察

摘要

OBJECTIVE:To study the adsorbability of plastic transfusion bottle and infusion set to diazepam. METHODS:With the reference of plastic-bottled 5% glucose injection,HPLC was used to determine the changes of mass concentration of diazepam adding into plastic-bottled 5% glucose injection at different time;disposable plastic infusion set was connected to simulate intrave-nous infusion and determine the changes of mass concentration of diazepam in the liquid effluent at different time. RESULTS:The mass concentration of diazepam in glass infusion bottles group was higher than in plastic transfusion bottles group. The adsorbabili-ties of solutions showed the strongest at the time of 15-20 min. The mass concentration of the effluent liquid from the glass bottle group was about 80% of the original concentration and plastic bottle group was about 67%. As the time went on,the adsorbability was gradually saturated at 60 min and the concentration rose again;the mass concentration of the effluent liquid from the glass bot-tle group returned to 95%of the original concentration at 80 min and the plastic bottle group was about 75%of the original concen-tration. CONCLUSIONS:Both plastic infusion bottle and infusion set have strong adsorbability to diazepam. It is suggested that the dosage of diazepam should be increased by 25% to 33% while plastic-bottled 5% glucose injection is used as solvent for intrave-nous drip.%目的：考察塑料输液瓶和输液器对地西泮的吸附性。方法：以玻璃瓶装的5％葡萄糖注射液为对照，采用高效液相色谱（HPLC）法测定地西泮加入塑料瓶装的5％葡萄糖注射液后放置不同时间的质量浓度变化；并连接一次性塑料输液器模拟静滴状态，于不同时间收集流出液体测定其中地西泮的质量浓度变化。结果：玻璃瓶组地西泮质量浓度高于塑料瓶组，两组溶液经过输液器15～20 min时吸附性最强，玻璃瓶组流出液体质量浓度约为初始浓度的80％，塑料瓶组约为67％；随着时间的延长，到60 min时吸附渐渐达到饱和状态，质量浓度回升；到80 min时玻璃瓶组流出液体质量浓度恢复到初始浓度的95％，塑料瓶组约为初始浓度的75％。结论：塑料输液瓶和输液器对地西泮均有较强的吸附作用，建议在使用塑料瓶装的5％葡萄糖注射液作为溶剂静脉滴注地西泮时，应增加25％～33％的用量。