目的：探讨氟尿嘧啶、卡培他滨、表柔比星、顺铂、伊立替康、紫杉醇、奥沙利铂和多西他赛致不良反应（ADR）的规律及特点，为临床合理用药提供参考。方法：采用回顾性研究方法，检索国内外发表的关于氟尿嘧啶、卡培他滨、表柔比星、顺铂、伊立替康、紫杉醇、奥沙利铂和多西他赛治疗胃癌致ADR病例报告，并就收集的ADR信息进行统计和分析。结果：最终纳入306篇文献，合计511例患者、663例次ADR。男女性别比例为1.30∶1，41～60岁有227例（占比48.19％）。ADR的临床表现主要以胃肠系统损害（273例次，占比41.18％）、心血管系统损害（156例次，占比23.53％）、呼吸系统损害（76例次，占比11.46％）较为多见，临床症状列前5位的分别是恶心（82例次）、呕吐（78例次）、骨髓抑制（69例次）、腹泻（52例次）和消化系统反应（41例次）。49.90％的患者在用药30 min内出现ADR，多数患者经对症治疗后均可好转或痊愈。结论：临床治疗胃癌时应针对易发生ADR的性别、年龄和累及器官系统等角度进行充分评估后给予患者用药，以减少ADR的发生。%OBJECTIVE:To explore the reules and characleristics of ADR reduced by fluorouracil,capecitabine,epirubicin, cisplatin,irinotecan,paclitaxel,oxaliplatin and docetaxel for patients with gastric cancer. METHODS:The Chinese and English lit-eratures about the reports of fluorouracil,capecitabine,epirubicin,cisplatin,irinotecan,paclitaxel,oxaliplatin and docetaxel in the treatment of gastric cancer were extracted,and statistical analysis was carried out for the included studies. RESULTS:Totally 306 were chosen,including 511 patients involving 663 cases. The ration of male to female was 1.30∶1,227 cases aged 41-60 years old (accounting for 48.19%),ADR mainly included gastrointestinal damage(273 cases,accounting for 41.18%),cardiovascular system damage(156 cases,accounting for 23.5%),respiratory system(76 cases,accounting for 11.46%),mainly fifth were nausea (82 cases),vomiting(78 cases),bone marrow suppression(69 cases),diarrhea(52 cases)and digestive system reaotions(41 cas-es). 49.90% patients showed drug adverse reactions within 30 minutes,most patients were improved to heal. CONCLUSIONS:Prompt medical workers pay attention to patients age,sex,and the accumulative system in treatment with stomach cancer ,reduce the occurrence of adverse drug reactions.
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