输液滴速对注射用硫普罗宁治疗肝功能异常疗效的影响

摘要

目的：：探讨注射用硫普罗宁与溶媒配伍后的输液滴速对肝功能异常疗效的影响。方法：采用单纯硫普罗宁治疗的肝功能异常患者74例随机分为观察组与对照组各37例,观察组硫普罗宁输液滴速为60~65滴/min,输液时间控制在1 h内；对照组输液滴速为30~35滴/min,输液时间控制在2 h内；疗程均为4周。比较两组患者临床疗效及肝功能改善情况。结果：观察组总有效率为83.78%,明显优于对照组的56.76%(P<0.05)；两组的AST、ALT、TBIL均比治疗前明显下降(P<0.05),且观察组降低幅度明显优于对照组(P<0.05)。结论：注射用硫普罗宁在临床应用中,严格控制输液时间和输液滴速,能有效的提高其临床疗效。%Objective:To explore the influence of infusion drop speed on the efficacy of tiopronin for injection combined with sol-vents in the treatment of abnormal liver function. Methods:Totally 74 patients were randomly divided into the observation group and the control group with 37 ones in each. The infusion drop speed was 60-65 drops per minute in the observation group, and that was 30-35 drops per minute in the control group, and the infusion time was controlled in 1h in the observation group and 2h in the control group. The clinical effect and the improvement of liver function were compared between the two groups after a treatment course of 4 weeks. Results:The total effective rate of the observation group(83. 78%) was obviously higher than that in the control group(56. 76%) (P<0. 05) after the treatment, and ALT, AST and TBIL of liver function indices were improved obviously except for ALB in the two group, and the difference was statistically significant between the two groups(P<0. 05). Conclusion:Tiopronin for injection can effectively improve the clinical effect by strictly controlling the time and drop speed of infusion.