目的 观察金莲花总黄酮镇痛、解热、抗炎作用的效果.方法 实验动物采用热板法与醋酸扭体法、家兔与大鼠致热法、耳廓渗出与棉球肉芽法测定金莲花总黄酮的镇痛、解热、抗炎效果.结果 金莲花0.8,0.4,0.2 g/kg剂量组,在给药90 min,小鼠疼痛阈值提高47.6％,39.9％,14.2％,扭体抑制率为31.6％,28.5％,12.1％;对家兔解热作用可持续5h,对大鼠解热作用可持续4h,解热作用2h后最明显;对小鼠耳壳炎性渗出抑制率为22.6％,29.7％,14.4％,对大鼠棉球肉芽肿抑制率为43.9％,24.6％,5.3％.结论 金莲花总黄酮具有镇痛、解热、抗炎作用,作用强度呈量效关系.%Objective To observe the analgesic, antipyretic and anti - inflammatory effects of total flavone in Trollius Chinensis Bge. . Methods The experimental animals were performed the hot plate,acetic acid writhing,rabbit and rat induced fever,earlap exudation and cottonball granuloma methods for determining the analgesic, antipyretic and anti - inflammatory effects of total flavone in Trollius chinensis Bge. Results In the total flavone dose groups of 0. 8 g/kg,0. 4 g/kg and 0.2 g/kg,mice pain threshold were increased by 47.6％ ,39.9％ and 14.2％ within 90 min after medication, the writhing inhibiting rates were 31.6％ ,28.5％ and 12. 1％ ,the rabbit antipyretic effects could lasted for 5 h and the rat antipyretic effects could lasted for 4 h. The antipyretic effect was most obvious after 2 h. The inhibiting rates of mice earlap inflammatory exudation were 22.6％ , 29.7％ and 14.4％. The inhibiting rates of rat cottenball granyloma were 43.9％ ,24.6％ and 5.3％ , respectively. Conclusion Total flavone in Trollius Chinensis Bge. has significant analgesic, antipyretic and anti - inflammatory effects and the effect intensity presents a dose - reaction relation
展开▼
