聚维酮碘与妥布霉素用于术中结膜囊冲洗的抗菌效果对比

摘要

Objective To compare the antibacterial efficacy of povidone-iodine and tobramycin for flushing conjunctival sac in cataract surgery. Methods 200 patients with cataract operation were randomly assigned to the group A and B. Tobramycin and povidone-iodine were respectively given to these two groups. The conjunctival sac germ-carrying situation before the topical application of Levofloxacin Eye Drops and after using tobramycin and povidone-iodine was detected. And the adverse reactions were observed in the two gorups. Results The conjunctival sac bacteria-carrying situation before using topical Levofloxacin Eye Drops in the two groups had no statistic difference ( P ﹥ 0. 05 ) . After flushing conjunctival sac, the bacterial detection rate of conjunctival sac in the group A was signif-icantly higher than that in the group B. 4 cases of corneal edema in the group B appeared ( P ﹤ 0. 05 ) . All cases were followed up for 1 month without endophthalmitis. Conclusions Using povidone-iodine flushing before operation is more effective than tobramycin for decreasing the conjunctival bacteria-carrying rate and is a better and more effective sterilization measure.%目的：对比白内障术中结膜囊内应用聚维酮碘与妥布霉素冲洗后的抗菌效果。方法将白内障手术患者200例随机均分为A组和B组，术前分别使用妥布霉素和聚维酮碘冲洗。检测左氧氟沙星滴眼液使用前所有患者结膜囊带菌情况，以及结膜囊使用聚维酮碘与妥布霉素冲洗后带菌情况，并观察药品不良反应。结果使用左氧氟沙星滴眼液前，两组间结膜囊带菌情况无统计学差异( P﹥0.05)。结膜囊冲洗后，A组结膜囊细菌检出率明显高于B组( P﹤0.05)。A组患者未发生药品不良反应，B组出现4例角膜水肿。所有患者随访1个月均未发生眼内炎。结论术前结膜囊内使用聚维酮碘冲洗较妥布霉素能有效降低结膜囊带菌率，是更有效的杀菌措施。