目的 探讨老年肺癌患者化学治疗(简称化疗)后生存期的影响因素.方法 回顾性分析2010年1月至2012年1月医院收治的91例住院化疗老年原发性肺癌患者的临床资料,采用Kaplan-Meier法计算总生存期(OS)及1,3,5年生存率,采用Cox回归分析OS影响因素.结果 1,3,5年生存率分别为59.34%,23.08%,10.99%,中位OS为18.23个月(8~77个月).单因素分析表明,Karnofsky(KPS)评分、肿瘤分期、淋巴转移、早期手术、晚期化疗方案、化疗疗程、放射治疗(简称放疗)对OS均有明显影响(P<0.05);Cox多因素分析显示,KPS评分、肿瘤分期、淋巴转移、化疗疗程是影响OS的独立因素(P<0.05).结论 肿瘤分期、淋巴转移、功能状态、化疗疗程是影响老年肺癌患者生存期的独立因素,患者体力状态良好时早期手术、4个及以上周期化疗及辅助放疗等有利于延长生存期.%Objective To investigate the survival conditions of elderly patients with lung cancer after chemotherapy and to evaluate the influencing factors on survival period. Methods The clinical characteristics of 91 elderly patients with lung cancer who received chemotherapy in our hospital from January 2010 to January 2012 were retrospectively reviewed. Kaplan- Meier test was used to calcu-late the overall survival ( OS ) and 1-year, 3-year, 5-year survival rate, Cox regression was used to detect the influencing factors on OS of the patients. Results The 1-year, 3-year and 5-year survival rate in this study were 59. 34% 23. 08% 10. 99%, respectively, and the median OS was 18. 23 months ( 8-77 months ); The single-factor analysis showed that KPS score, tumor stage, lymph node metastasis, early surgery, late chemotherapy regimen, chemotherapy course, radiotherapy had significant effects on OS ( P < 0. 05 );The re-sults of Cox multiple regression analysis showed that KPS score, clinical stage, lymph node metastasis, chemotherapy course were indepen-dent factors influencing the OS ( P < 0. 05 ) . Conclusion The tumor staging, lymph node metastasis, functional status and chemotherapy course are independent factors influencing the survival period. Patients may improve survival period if receiving surgery early, more than equal to 4 courses chemotherapy and/or adjuvant radiotherapy when they have good functional status.
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