RUNX3基因rs760805多态性与胃癌的关系

摘要

背景与目的：人类Runt相关转录因子3(runt-related transcription factor 3，RUNX3)基因与胃癌发生、发展有着极其密切的关系，rs760805 AA基因型与胃癌的发病有关。本研究拟初步探讨RUNX3基因rs760805多态性与中国汉族人群胃癌发病风险的关系。方法：以DNA直接测序法判定310例胃癌患者(胃癌组)和327例健康对照者(对照组)的RUNX3 rs760805的基因型，分析rs760805基因型与胃癌发病风险之间的关系。结果：胃癌组与对照组的RUNX3 rs760805基因型分布频率差异有统计学意义(P<0.05)。与TT基因型相比，携带AA基因型能显著增加胃癌的发病风险(AA：OR=1.83，95%CI：1.15~2.92，AT：OR=1.24，95%CI：0.81~1.92)。结论：RUNX3 rs760805 AA基因型与中国汉族人群的胃癌发病有关。%Background and purpose:Runt-related transcription factor 3 (RUNX3) has a signiifcant relation with gastric cancer. Many researches have confirmed that rs760805 AA can increase the risk of gastric cancer. The purpose of the study was to investigate the relationship between the rs760805 polymorphism of the RUNX3 gene and gastric cancer. Methods: The rs760805 genotypes were determined by PCR-based DNA sequence measuring analysis and direct DNA sequencing in 310 incident cases with gastric cancer and 327 controls recruited in Shandong. Results:The frequency of TT genotype was 15.16%in gastric cancer patients and 20.49%in normal controls, and the corresponding percentages for AT and AA genotypes were 48.39%and 36.45%, and 52.60%and 26.91%, respectively. Compared to TT genotype, AT genotypes were associated with an increased risk of gastric cancer (OR=1.24, 95%CI`:0.81-1.92;OR=1.83, 95%CI:1.15-2.92). Conclusion:The rs760805 polymorphism of the RUNX3 gene is associated with increased susceptibility to gastric cancer.