长链非编码RNA在泌尿系统肿瘤中的研究进展

摘要

Long non-coding RNAs (lncRNAs) are deifned as transcripts longer than 200 nt without coding capacities. Although they were initially argued to be transcriptional by-products of RNA polymeraseⅡ, recent evidence suggests that lncRNAs have been associated with a spectrum of biological processes, and aberrant lncRNA expression may be a major contributor to tumorigenesis, progression and prognosis. This study summarizes the up-to-date studies on lncRNAs in urological neoplasms.%长链非编码RNA(long non-coding RNA，lncRNA)是一类长度大于200个的核苷酸，并不具备编码蛋白质功能的基因转录产物。它最初被认为是RNA聚合酶Ⅱ转录的副产物，并不具有任何生物学功能。但最近的研究表明，lncRNA可以在多个层面参与人体内多种重要的调控过程，并且与肿瘤的发生、发展及预后密切相关。本研究对在泌尿系统肿瘤中的研究进展作一综述。