宫颈细胞TBS+DNA倍体定量检测在宫颈病变中的应用

摘要

Objective:The purpose of cervical cells by TBS + DNA ploidy quantitative detection, early detection of cervi-cal lesions, blocked the occurrence of cervical cancer. Methods: Gynecology clinics of 1 000 eases of cervical cells, women in TBS + DNA ploidy quantitative tests in patients with positive cervical biopsy done. Diagnostic criteria for the use of TBS classification systems. Results: 1 000 cases of women in cervical serape specimens films, TBS + DNA ploidy in 53 cases of positive quantitative detection, the positive rate was 5.3%, in which atypical glandular cells (AGCUS) 2 cases, low-grade squamous intraepithelial lesion (LSIL) 40 cases, a high degree of squamous intraepithelial lesion (HSIL) 9 cases of squamous cell carcinoma (SCC) 2 cases. Positive for 53 eases of cervical biopsy, which mild atypical glandular hyper-plasia and 2 eases, CIN Ⅰ 39 cases, CIN Ⅱ 7 cases, CIN Ⅲ 3 cases, scc 2 cases. Cervical biopsy of TBS + DNA ploidy provide positive detection of lesions to be diagnosed. Ages 30-40 years of age is the age of high incidence of CIN, the probability was 30/53 (56.6%). Conclusion:Cervical cells TBS+DNA ploidy and quantitative determination of some histological correlation. TBS+DNA quantitative determination of ploidy as a non-invasive detection of out-patient screening is an effective method for cervical cancer. Screening for cervical cancer patient to pay special attention to young women.%目的:通过对宫颈细胞TBS+DNA倍体定量检测,及早发现宫颈病变,阻断官颈癌的发生.方法:对妇科门诊就诊的1 000例妇女进行宫颈细胞TBS+DNA倍体定量检测,阳性患者再做官颈活检.诊断标准采用TBS分类系统.结果:1 000例妇女官颈刮片标本,TBS+DNA倍体定量检测阳性53例,阳性率为5.3%,其中不典型腺细胞(AGCUS)2例,低度鳞状上皮内病变(LSIL)40例,高度鳞状上皮内病变(HSIL)9例,鳞状细胞癌(SCC)2例.53例阳性者进行宫颈活检,其中轻度不典型腺上皮增生2例,CIN Ⅰ 39例,CIN Ⅱ 7例,CINⅢ3例,SCC 2例.宫颈活检对TBS+DNA倍体检测提供的阳性病变加以确诊.30～40岁年龄阶段是CIN的高发年龄,发病率为56.6%(30/53).结论:宫颈细胞TBS+DNA倍体定量测定与病理组织学有一定的相关性.TBS+DNA倍体定量测定作为无创伤检测是门诊筛查子宫颈癌的有效方法.对年轻妇女应特别关注宫颈癌的门诊筛查工作.