Objective: To study the metabolic features of obese and nonobese women with polycystic ovary syndrome. Methods: Glycemia and insulin (INS) response to the tolerance test with 75 g oral glucose load and serum levels of lutein-inzing hormone (LH) , follicle stimulating hormone (FSH),estradiol(E2), testosterone(T) prolactin(PRL) were assessed in 47 PCOS patients. Results:①The IR rate was 25.5% in the 47 patients,44.4%in obese patients and 13.8% in nonobese patients. There was significant differences in the incidence of IR between obese PCOS patients and nonobese PCOS patients. ②The incidence of Diabetes mellitus was 2.1% and tne incidence of IGT was 8.5%, There were no significant differences in the incidence of Diabetes mellitus and IGT between obese PCOS patients and nonobese PCOS patients.③T level was higher in obese and nonobese PCOS patients than normal,but there were no significant differences between the two groups. ④The differenciation between the level of sex hormone had no significance. Conclusion :The obese group shows high levels of in-sulin resistence than that in nonobese group,which may have some health implications later in life.%目的:研究肥胖和非肥胖多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者的代谢特征,为临床治疗提供理论依据.方法:47例PCOS患者,根据体重指数分为肥胖组和非肥胖组,口服75 g葡萄糖,做糖耐量及胰岛素释放试验.于月经周期第2～5天或B超监测无优势卵泡时抽取静脉血,测基础内分泌水平.用卡方检验及t检验比较两组之间的代谢特征.结果:排除年龄因素,进行统计学分析,①47例PcOs患者中有1例达到糖尿病诊断标准,发生率为2.1%(1/47);4例达到糖耐量低减诊断标准,发生率为8.5%(4/47).两组患者糖尿病和糖耐量低减的发生率差异无统计学意义;②肥胖组空腹血糖及60 min血糖明显高于非肥胖组,t检验结果显示两者之间的差异有统计学意义,P<0.05.③47例PCOS患者总的胰岛素抵抗发生率为25.5%,其中肥胖组胰岛素抵抗发生率为44.4%,非肥胖组胰岛素抵抗发生率为13.8%,两组PCOS患者胰岛索抵抗发生率差异无统计学意义,χ2=3.994,P<0.05.④肥胖组和非肥胖组妇科内分泌激素水平的比较,差异无统计学意义,但两组均表现为高雄激素状态.结论:对PCOS患者而言,空腹血糖水平难以作为糖尿病的预测指标和危险因子,应做糖耐量试验及胰岛素释放试验;肥胖PCOS患者胰岛素抵抗发生率明显高于非肥胖PCOS患者;高雄激素血症是PCOS的基本特征之一,降雄激素治疗是治疗PCOS的一个突破口.
展开▼
