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Discovery of Novel N-Nicotinamide Methyltransferase Inhibitors to Combat Obesity-Linked Osteoarthritis and Metabolic Disease Among Veterans and Beneficiaries.

机译：发现新的N-烟酰胺甲基转移酶抑制剂，以对抗退伍军人和受益者中肥胖相关的骨关节炎和代谢疾病。

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作者
Watowich, S. J.;
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年度 2016
页码 1-57
总页数 57
原文格式 PDF
正文语种 eng
中图分类
关键词
Metabolic diseases; Obesity; Arthritis; Drugs; Inhibitors; Assays; Nnmt (nicotinamide n-methyltransferase); Osteoarthritis; Drug candidates; Nnmt inhibitors; Small molecules;

机译：代谢疾病;肥胖症;关节炎;药物;抑制剂;检测; Nnmt（烟酰胺n-甲基转移酶）;骨关节炎;候选药物; Nnmt抑制剂;小分子;

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1. Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease [J] . Chirag N. Patel, John J. Georrge, Krunal M. Modi, Journal of Biomolecular Structure and Dynamics . 2018,第15a16期

机译：基于药疗法的虚拟筛选儿茶酚-O-甲基转移酶（COMT）抑制剂，用于打击阿尔茨海默病
2. Discovery of the First-in-Class GSK-3 beta/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease (vol 10, pg 469, 2019) [J] . De Simone Angela, La Pietra Valeria, Betari Nibal, ACS medicinal chemistry letters . 2019,第9期

机译：发现一流的GSK-3β/ HDAC双抑制剂作为疾病改性剂，用于打击阿尔茨海默病（第10卷，PG 469,2019）
3. Discovery of the First-in-Class GSK-3 beta/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease [J] . De Simone Angela, La Pietra Valeria, Betari Nibal, ACS medicinal chemistry letters . 2019,第4期

机译：发现一流的GSK-3β/ HDAC双抑制剂作为疾病改性剂，用于打击阿尔茨海默病
4. Discovery of Natural Product Compounds as Dengue Virus NS5 Methyltransferase Inhibitor Candidate through in Silico Method [C] . Anjas Randy Bagastama, Ahmad Husein Alkaff, Usman Sumo Friend Tambunan International Conference on Science and Technology . 2020

机译：在硅方法中发现天然产品化合物作为登革热病毒NS5甲基转移酶抑制剂候选者
5. Epigenetic Targeted Drug Discovery: Inhibitors of Methyltransferase G9a and Dual Inhibitors of G9a and HDAC [D] . Soumyanarayanan, Uttara. 2016

机译：表观遗传靶向药物发现：甲基转移酶G9a的抑制剂和G9a和HDAC的双重抑制剂
6. Discovery of the First-in-Class GSK-3β/HDACDual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’sDisease [O] . Angela De Simone, Valeria La Pietra, Nibal Betari, 2019

机译：发现一流的GSK-3β/ HDAC双重抑制剂作为抗病药可对抗阿尔茨海默氏病疾病
7. Correction to “Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease” [O] . Angela De Simone, Valeria La Pietra, Nibal Betari, 2019

机译：纠正“发现一流的GSK-3β/ HDAC双抑制剂作为疾病改性剂来打击阿尔茨海默病的”

Discovery of Novel N-Nicotinamide Methyltransferase Inhibitors to Combat Obesity-Linked Osteoarthritis and Metabolic Disease Among Veterans and Beneficiaries.

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