粉防己碱对急性脑梗死患者血清胆红素的影响

摘要

目的：探讨粉防己碱对急性脑梗死患者血清胆红素水平的影响。方法将符合要求的140例急性脑梗死患者随机分为治疗组和对照组，每组70例。两组患者均给予常规治疗，如改善脑循环、抗血小板聚集、调脂、脑保护等，治疗组在此基础上加用粉防己碱片剂口服。治疗前后进行血清胆红素水平测定，并对神经功能缺损进行评分。结果治疗前两组血清胆红素含量差异无统计学意义(P>0.05)；治疗后两组血清胆红素水平均升高，治疗后第7天达到最高水平，治疗组治疗后7、14 d血清胆红素水平高于对照组，差异有统计学意义(P<0.05)。治疗后7、14 d治疗组神经功能缺损程度评分低于对照组，差异有统计学意义(P<0.05)。结论粉防己碱治疗急性脑梗死可升高患者的血清胆红素水平，减轻脑组织损伤和减少神经功能缺损。%Objective To investigate the influence of tetrandrine on serum bilirubin in patients with acute cerebral in-farction (ACI). Methods One hundred and forty patients with ACI meeting the criteria were evenly divided into treat-ment group and control group in random.Regular treatments like improvement of cerebral circulation,anti-platelet ag-gregation,lipid regulation,and cerebral protection,etc. were provided in the two groups.Tetrandrine tablet for oral admin-istration was added to the treatment group on the basis of regular treatment.The levels of serum bilirubin before and af-ter therapy were tested and neurologic impairment was scored in order to compare whether there were differences in the two groups. Results There was no significant difference in the content of serum bilirubin before treatment in the two groups (P>0.05).After therapy,the level of serum bilirubin in both groups increased,and reached the highest level in 7th day.The levels of serum bilirubin 7 and 14 days after therapy in the treatment group were both higher than those in the control group,with statistical differences (P<0.05).The scores of neurologic impairment 7 and 14 days after therapy in the treatment group were both lower than those in the control group,which displayed statistical significances (P<0.05). Conclusion In the treatment of ACI,tetrandrine can increase the level of serum bilirubin,relieve cerebral injury,and re-duce neurologic impairment.