胃癌和胃癌前病变COX-2表达与Hp感染的相关性研究

摘要

目的：探讨诱生型环氧合酶(COX-2)在胃癌和胃癌前病变中的表达及其与幽门螺杆菌(Hp)的相关性。方法选取本院2010年3月~2013年3月收治的30例胃癌患者(A组)、60例萎缩性胃炎患者(B组)、30例浅表性胃炎患者(C组),使用免疫组织化学法对3组患者的胃黏膜COX-2水平进行检测。结果 B组肠上皮化生(IM)患者的Hp阳性检出率最高,异型增生(Dys)与A组的Hp阳性检出率、COX-2阳性检出率次之。 A、B组的Hp阳性检出率均显著高于C组患者,差异均有统计学意义(P<0.05)；在GCa、Dys、IM中均可检测到COX-2蛋白表达,3组差异均无统计学意义(P>0.05)；COX-2阳性在Hp阳性胃黏膜病变中的检出率显著高于Hp阴性胃黏膜病变(P<0.05)。结论 Hp感染可促进胃癌细胞的COX-2表达,COX-2表达过度、Hp感染都是胃癌发生的重要因素。%Objective To investigate the inducible cyclooxygenase (COX-2) in gastric precancerous lesions and expres-sion,and correlation of COX-2 and Hp. Methods 30 cases of gastric cancer (group A),60 cases of atrophic gastritis pa-tients (group B),30 cases of superficial gastritis patients (group C) in our hospital from March 2010 to March 2013 were treated,the mucosal COX-2 levels of three groups were detected by immunohistochemical method. Results Hp positive detection rate of IM patients in group B were highest,Hp positive detection rate,COX-2 positive detection rate were the second in Dys and group A,Hp positive detection rate in group A and B were significantly higher than those of group C, the differences were statistically significant (P<0.05).In GCa,Dys,IM could be detected in the cox-2 protein expression, no statistically significant difference were observed in the three groups (P>0.05)COX-2 positive detection rate in Hp positive gastric mucosa lesions was significantly higher than that in Hp negative gastric mucosa lesions (P<0.05). Con-clusion Hp infection may promote COX-2 expression in gastric cancer cells,COX-2 expression over,Hp infection is an important factor in gastric cancer.