抗病毒治疗对慢性乙型肝炎患者调节性T细胞影响的研究进展

摘要

慢性乙型肝炎患者抗病毒治疗在抑制病毒复制的同时也影响机体免疫功能。调节性T细胞为体内具有免疫调节功能的T细胞亚群，能抑制HBV感染者特异性T细胞反应。研究慢性乙型肝炎患者抗病毒治疗对调节性T细胞数量及功能的影响，可以为探索更理想的免疫学指标来评价抗病毒应答反应，治疗效果，预测治疗终点、停药后复发，疾病预后等打下基础，也可能为慢性乙型肝炎患者制订更优化的抗病毒治疗策略确定方向。%Antiviral therapy inhibits viral replication and also has some influence on body’s immunity in patients with chronic hepatitis B.Regulatory T cell,a subset of T cells,has an immunomodulatory function in v iv o and can inhibit spe-cific T cell response in HBV infection patients.Study of antiviral therapy influencing on amount of regulatory T cell and its function in patients with chronic hepatitis B can lay foundations for probing into more ideal immunological indica-tors to assess the anti-viral responses,therapeutic efficacy,predict the termination of treatment and recurrence after ceasing medication,disease prognosis,and may also point out the direction for developing more optimal strategies of an-tiviral treatment in patients with chronic hepatitis B.