扩张性心肌病患者SUA水平与FMR的相关性研究

摘要

Objective To explore the correlation of serum uric acid (SUA) level and functional mitral regurgitation (FMR) in patients with dilated cardiomyopathy aiming at providing the basis for clinical diagnosis and treatment. Methods 62 patients definitely diagnosed as dilated cardiomyopathy from October 2012 to October 2014 in our hospital selected as the research objects.After admission,the SUA,plasma B-type natriuretic peptide (BNP),cardiac ultrasonogra-phy for left ventricular ejection fraction (LVEF),ERO of mitral valve for the determination of regurgitation degrees and mitral tenting area during systole were tested.The SUA,BNP,LVEF and MVA in patients with different NYHA grading was compared respectively.The level of SUA in FMR at different degrees was also compared in order to analyze the correlation of SUA level and MVA. Results The higher the NYHA grading was,the higher the levels of SUA and BNP were,the lower the LVEF value was,and the larger the MVA was (P<0.05).The level of SUA in patients with severe FMR was greatly higher than that in patients with moderate-mild FMR,with significant difference (P<0.05).Correlation analysis showed that the level of SUA had an obviously positive correlation with MVA in patients with dilated car-diomyopathy (r=0.32,P<0.01). Conclusion The level of SUA has a correlation with FMR in patients with dilated car-diomyopathy.%目的：探讨扩张性心肌病患者血清尿酸(SUA)水平与功能性二尖瓣反流(FMR)的相关性，为临床诊治提供依据。方法选取2012年10月~2014年10月在本院就诊并明确诊断为扩展性心肌病的62例患者作为研究对象，入院后行SUA检测、血浆B型脑钠肽(BNP)检测和心脏超声检测，测量其左室射血分数(LVEF)，检测二尖瓣反流口面积(ERO)，确定二尖瓣反流程度，并检测心脏收缩期二尖瓣幕状区面积(MVA)。比较不同NYHA分级患者的SUA、BNP、LVEF和MVA以及不同程度FMR患者血清中的SUA水平，分析SUA水平与MVA的相关性。结果 NYHA评级越高，其SUA、BNP水平也越高，LVEF值越低，MVA则越大(P<0.05)。重度FMR患者的SUA水平显著高于中轻度FMR患者，差异有统计学意义(P<0.05)。相关性分析显示，扩张性心肌病患者的SUA水平与MVA呈正相关(r=0.32，P<0.01)。结论扩张性心肌病患者的SUA水平与FMR具有相关性。