产前筛查梅毒螺旋体的三种方法在梅毒诊断中的研究

摘要

Objective To explore the application value of three different detection methods in the diagnosis of syphilis. Methods 500 pregnant women from July 2014 to December in our hospital were selected as the research objects.The detection methods of TPPA,colloidal gold and TRUST for screening was used respectively.The result was compared. Results Among 500 cases of pregnant women during pregnancy,52 cases were in syphilis positive,and the rest were in negative.There was no significant difference in sensitivity,specificity,negative predictive value or positive predictive val-ue by these three detection methods (P>0.05).Among 56 TPPA positive specimens,53 casess were in positive titer by TRUST,and the rest three specimens were negative by the original serum,which were false negative when diluted by 64 times. Conclusion Three detection methods have the advantages in the detection of the prenatal screening for syphilis in the diagnosis of syphilis.%目的：探讨三种不同检测方法在梅毒诊断中的应用价值。方法选取本院2014年7~12月收治的500例孕妇作为研究对象，分别通过TPPA法、胶体金法和TRUST进行筛查，比较其检测结果。结果在500例妊娠期孕妇中，梅毒阳性52例，阴性448例。三种检测方法的敏感度、特异度、阴性预测值和阳性预测值比较，差异无统计学意义(P跃0.05)。56例TPPA阳性标本中，53例TRUST滴度阳性，3例血清原倍为阴性，通过血清64倍稀释后为假阴性。结论三种检测方法在产前筛查梅毒螺旋体检测中各有优势。