精神分裂症患者的高血糖发生率及相关因素分析

摘要

Objective To Analyze the related factors and incidence of hyperglycemia in patients with schizophrenia. Methods Clinical data of 336 cases with schizophrenia treated in our hospital from January to December 2013 were retrospectively analyzed,the incidence of hyperglycemia was counted,and related factors of hyperglycemia in patients with schizophrenia was analyzed. Results 42 cases (12.5%) of 336 patients combined with hyperglycemia,and 15 cases (4.5%) were diagnosed with diabetes.Negative symptom scores of patients with hyperglycemia was 28.2±6.9,higher than national norm (22.18±7.92),the difference was significant (P<0.01).Patients combined with hyperglycemia was older than that of patients without hyperglycemia,course of disease was longer,and negative symptom score was higher than that of patients without hyperglycemia,the difference was significant (P<0.01).Multi factor analysis showed that the course of disease,negative symptoms,hyperglycemia was associated with hyperglycemia (P<0.05 or P<0.01). Conclusion The inci-dence of hyperglycemia in patients with schizophrenia is high,and the negative symptom is obvious.The longer the dura-tion,the higher negative symptom,the greater the risk of hyperglycemia.%目的：分析精神分裂症患者高血糖的发生率以及相关因素。方法回顾性分析2013年1~12月在本院治疗的336例精神分裂症患者的临床资料，统计高血糖的发生率，并分析与精神分裂症患者合并高血糖的相关因素。结果336例患者中有42例(12.5%)合并高血糖，15例(4.5%)确诊为糖尿病。合并高血糖的患者阴性症状评分为(28.2±6.9)分，显著高于国内常模的(22.18±7.92)分，差异有统计学意义(P<0.01)。合并高血糖患者年龄显著大于未合并高血糖患者，病程显著长于未合并高血糖患者，阴性症状得分显著高于未合并高血糖患者，差异有统计学意义(P<0.01)。多因素回归分析显示，病程、阴性症状评分与患者合并高血糖相关(P<0.05或P<0.01)。结论精神分裂症患者的高血糖发生率较高，患者阴性症状突出，病程越长、阴性症状分越高，患者合并高血糖的风险越大。