老年精神分裂症患者肝胆彩超检查异常的发生率及相关因素分析

摘要

Objective:To explore the result of liver and gallbladder color Doppler ultrasonography in elderly patients with schizophrenia.Method:Three hundred and eighty elderly schizophrenia patients treated in our hospital from Apr.2008 to Apr.2012 were divided into abnormal group and control group according to liver ultrasound results.The clinical data were analyzed retrospectively.Single factor chi-square test and multi factor Logistic regression analysis were conducted to explore the influencing factors of abdominal ultrasound abnormalities in schizophrenia patients.Results:There were 201 patients with abnormal liver ultrasound results,including fatty liver,gallbladder stones,gallbladder polyps,liver cysts and acute or chronic cholecystitis.There was no significant difference in sex ratio between two groups(P>0.05).The proportions of single typical antipsychotic drugs,drug combination,course≥10 years and ≥70 years old patients were higher in the abnormal group than those in the control group(P<0.05).Through Logistic analysis,types of medication,medication methods,age and course of disease were influencing factors of abnormal liver and gallbladder in senile schizophrenia patients.Conclusion:The type,usage,course of disease and patient age are all risk factors of abnormal liver and gallbladder color Doppler ultrasound in elderly patients with schizophrenia.%目的:探究老年精神分裂症患者肝胆彩超检查异常情况及其影响因素. 方法:对380例老年精神分裂症患者进行腹部彩色多普勒超声检查,根据肝胆是否异常分为异常组和对照组比较两组患者临床资料,通过单因素卡方检验和多因素Logistic回归分析腹部超声异常的影响因素. 结果:异常组为201例,腹部彩超异常结果包括脂肪肝、胆囊结石、胆囊息肉、肝囊肿和急慢性胆囊炎;对照组为179例.经单因素卡方检验,两组性别差异无统计学意义(P>0.05);异常组服用单一典型抗精神病药、联合用药、病程≥10年、年龄≥70岁的比例均高于对照组,差异有统计学意义(x2=4.249,10.587,8.279,7.451;P<0.05).经多因素Logistic回归分析,服用单一典型抗精神病用药、联合用药、年龄≥70岁及病程≥10年均为老年精神分裂症患者肝胆彩超异常的危险因素. 结论:抗精神病类药物会对患者肝脏造成损伤,且与年龄、病程、用药种类及用药方法相关.