血清生化指标及凝血酶原时间在妊娠肝病患者检测中的意义

摘要

目的：探讨血清生化指标及凝血酶原时间(PT)在妊娠肝病患者检测中的意义。方法选择2012年1月~2014年1月本院妇产科产检及住院待产者共100例,根据有无合并肝病分为肝病组及正常妊娠组,各50例,抽取两组产妇静脉血1.8 ml,检测PT、部分凝血酶时间(APTT)、纤维蛋白原(FIB)及丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)、天冬氨酸氨基转移酶(AST)等指标,所有检测均在抽血后2 h内完成。结果肝病组ALT、GGT、AST较正常妊娠组明显升高,差异均有统计学意义(P<0.01)。肝病组PT、APTT较正常妊娠组升高,FIB较正常妊娠组降低,差异均有统计学意义(P<0.05)。结论对肝病患者进行血生化指标及PT检测对于临床鉴别与诊断、病情判断及预后具有重要的参考意义。%Objective To study the significance of serum biochemical indicator and prothrombin time (PT) in the detec-tion of pregnancy patients with liver disease. Methods Total of 100 patients from January 2012 to January 2014 in ob-stetrics and gynecology of our hospital for prenatal were chosen and divided into liver disease group and normal preg-nancy group according to the presence of combined liver disease,50 cases in each group.Venous blood for 1.8 ml was extracted from two groups of maternal,PT,thrombin time (APTT),fibrinogen (FIB),alanine aminotransferase (ALT),GGT,as-pertate aminotransferase (AST) were detected,all tests were completed within 2 hours after draw blood. Results ALT, GGT,AST of liver disease group was obviously higher than that of normal pregnancy group respectively,with statistical difference (P<0.01).PT,APTT of liver disease group was higher than that of normal pregnancy group respectively,FIB of liver disease group was lower than that of normal pregnancy group,with statistical difference(P<0.05). Conclusion Liver blood biochemical and PT test for clinical discrimination and diagnosis in pregnancy patients with liver disease has im-portant reference significance for the clinical identification and diagnosis,judgment and prognosis of illness.