The Effect of Chronic Liver Diseases on Some Biochemical Parameters in Patients Serum

摘要

Sixty two patients with chronic liver disease and 26 healthy individuals were included as normal controls for the study. Blood analysis was carried out for all of them which include serum bilirubin, total protein, creatinine and liver enzyme tests (GOT, GPT, ALP) levels. The result of blood parameters showed that: (total bilirubin and direct bilirubin (μmol/L)) have a higher level of bilirubin in viral groups (Chronic viral hepatitis) than in the cirrhosis and liver cancer patients, but all groups showed increased bilirubin levels more than in the control group (p<0.001). Liver enzyme tests show the concentration of serum Glutamic Pyruvic Transaminase (GPT), serum Glutamic Oxaloacetic Transaminase (GOT) and serum Alkaline Phosphates (ALP) levels are increased highly significant in cirrhotic patients compared to other groups of control patients (p<0.001). There was a decrease in total protein concentrations observed in cirrhosis and liver cancer (hepato-cellular Carcinoma) patients compared to the control group. The level of creatinine concentration for patients with cirrhosis and hepato-Cellular Carcinoma were increased highly significant (p<0.01) than other groups with Chronic virtal hepatitis and control groups.