纤溶系统分子标志物在妊娠高血压中的应用价值分析

摘要

Objective To observe application value of molecular marker with fibrinolytic system in gestational hyper-tension. Methods Women in our hospital from March 2013 to August 2014 were selected and divided into normal non-pregnancy group(n=20),normal late pregnancy group(n=20) and gestational hypertension group(n=50).Level of fib-rinogen(Fbg),tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1) and D-dimer were tested in all study objects. Results Level of Fbg,PAI-1,t-PA and D-dimer in normal late pregnancy group and gestational hy-pertension group was significantly higher than that in normal non-pregnancy group respectively(P<0.01).Compared with normal late pregnancy group,t-PA of gestational hypertension group as the illness disease without change(P<0.05).Com-pared with normal late pregnancy group,Fbg,PAI-1 and D-dimer of gestational hypertension group was significantly higher with exacerbation (P<0.01). Conclusion Fibrinolytic function in gestational hypertension patient with decreased obviously,fibrinolytic activity has been restricted,cause the body in a hypercoagulable state and severe prothrombotic state.Detection of plasma molecular marker of fibrinolytic system is helpful in the early diagnosis of prethrombotic state, is conducive to the prevention of thrombosis,and reduce the complication.%目的：观察纤溶系统分子标志物在妊娠高血压中的应用价值。方法选取2013年3月~2014年8月在本院住院的妇女分为正常非孕组20例、正常晚孕组20例和妊娠高血压组50例,检测所有研究对象的纤维蛋白原(Fbg)、组织纤溶酶原激活物(t-PA)及其抑制物-1(PAI-1)、D-二聚体(D-dimer)水平。结果正常晚孕组与妊娠高血压组Fbg、PAI-1、t-PA及D-dimer水平均显著高于正常非孕组(P<0.01)；与正常晚孕组比较,妊娠高血压组的t-PA随着病情病化无改变(P跃0.05),Fbg、PAI-1及D-dimer随着病情加重显著升高(P<0.01)。结论妊娠高血压患者的纤溶功能明显降低,纤溶活性受到抑制,导致机体血液呈高凝状态与严重的血栓前状态,检测血浆纤溶系统分子标志物,有助于早期发现血栓前状态,有利于预防血栓形成并减少并发症。