亚胺培南西司他丁钠在危重症感染降阶梯治疗中的效果观察

摘要

目的：观察亚胺培南西司他丁钠在危重症感染降阶梯治疗中的效果。方法对本院2013年5月~2014年5月入住到重症医学科需要呼吸机支撑呼吸的重度病危患者78例进行研究,随机分为两组,其中对照组39例,采用常规性的抗生素治疗；观察组39例,静脉滴注亚胺培南西司他丁钠治疗,3~5 d后两组均以细菌学检测和药物过敏试验结果为依据进行抗生素调整。结果观察组的机械通气时间短于对照组,呼吸机相关性肺炎发生率低于对照组,差异有统计学意义(P<0.05)。结论亚胺培南西司他丁钠早期治疗危重症感染者有效果,可较早稳定病情,缩短治疗过程、重症病房的入住时间及采用呼吸机维持呼吸的时间。%Objective To observe the effect of imipenem and cilastatin sodium in descending ladder treatment of criti-cally ill infection. Methods 78 patients with critically ill supported of respiratory ventilator admitted to the intensive care ward in our hospital from May 2013 to May 2014 were divided into two groups.Conventional antibiotics was used in control group(n=39),intravenous imipenem and cilastatin sodium was applied in observation group(n=39).After treat-ment of 3-5 days,antibiotics were adjusted based on the bacteriological detection and drug allergy test results in two groups. Results Mechanical ventilation time in observation group was shorter than that in control group,the incidence rate of pneumonia related ventilator in observation group was lower than that in control group,with statistical difference (P<0.05). Conclusion Imipenem and cilastatin sodium is effective in the treatment of critically ill early,it can early con-trol illness,shorten treatment process,check-in time of intensive care units and breathing time by using breathing ma-chine maintain.