终末期肾病患者动态血压参数与动脉粥样硬化的相关性研究

摘要

Objective To study the relationship between ambulatory blood pressure and atherosclerosis in patients with end stage renal disease. Methods 97 cases of patients with end stage renal disease in our hospital from May to Novem-ber 2011 were selected,who were not start carrying out blood purification therapy or taken with hemodialysis regularly more than 3 months,and the age were mort than 18 years.According to the carotid artery ultrasound,carotid plaque for-mation and (or) internal carotid artery intima thickening was as atherosclerosis group,no obvious abnormalities was as control group.Logistic regression analysis was used to analyze the correlation. Results Average daytime diastolic blood pressure,diastolic blood pressure at night,24 h average pulse pressure,average daytime pulse pressure,average pulse pressure at night between the two groups had significant (P<0.05).Logistic regression analysis showed that,average 24 h diastolic blood pressure,diastolic blood pressure at night,24 h average pulse pressure,and average pulse pressure at night was was related to atherosclerosis closely. Conclusion There is good relationship between ambulatory blood pres-sure and atherosclerosis,can guide clinicians with early intervention,eliminate the influence of abnormal blood pressure on the lifting of chronic kidney disease,may be caused by atherosclerosis risk.%目的：研究终末期肾病患者动态血压参数与动脉粥样硬化的相关性。方法收集本院2011年5~11月未开始血液净化治疗或规律采用血液透析≥3个月且年龄跃18岁的终末期肾病患者97例,根据颈动脉超声检查颈动脉斑块形成和(或)颈动脉内中膜增厚者为动脉粥样硬化组,无明显异常者为对照组。采用二项分类变量Lo-gistic回归分析进行相关性分析。结果两组日间平均舒张压、夜间平均舒张压、24 h平均脉压、日间平均脉压、夜间平均脉压比较,差异有统计学意义(P<0.05)。 Logistic回归分析显示,24 h平均舒张压、夜间平均舒张压、24 h平均脉压及夜间平均脉压与动脉粥样硬化密切相关。结论动态血压参数与动脉粥样硬化相关性良好,可指导临床医生早期干预,解除血压异常对慢性肾病的影响,解除可能引起的动脉粥样硬化风险。