盐酸戊乙奎醚治疗急性有机磷农药中毒的临床效果

摘要

Objective To investigate the clinical effect and safety of penehyclidine hydrochloride treating acute organophosphorus pesticide poisoning (AOPP). Methods 120 cases with AOPP were randomly divided into the two groups.The observation group (n=60) was given penehyclidine hydrochloride,and the control group was given atropine. The detoxifying effect and the incidence rate of adverse reaction in the two groups were compared. Results The total ef-fective rate of the observation group was 93.33%,while the control group was 80.00%,the curative effect of the observa-tion group was obviously better than that in the control group (P<0.05);the muscarinic-like symptom duration was (1.70±0.45) h,nicotine-like symptom duration was (6.38±2.09) h,and duration of symptom of central nervous system was (12.50±3.22) h in the observation group,above-mentioned indicators in the observation was significantly shorter than that in the control group respectively [(2.31±0.52),(10.25±4.88),(18.37±3.16) h] (P<0.05);the disturbance consciousness recovery time was (23.46±11.30) h,ChE activity recovery time was (46.81±13.27) h and hospital stay was (7.03±2.85) d in the obser-vation group,above-mentioned indicators in the observation group was significantly shorter than that in the control group respectively [(40.58±12.35)h, (63.50±18.94)h,(11.52±3.06)d] (P<0.05);the incidence rate of heartbeat tachycardia, agitation,blurred vision,retention of urine and so on in the observation group was lower than that in the control group re-spectively (P<0.05). Conclusion Penehyclidine hydrochloride used in rescuing AOPP is safer and more effective.%目的：探讨盐酸戊乙奎醚治疗急性有机磷农药中毒(AOPP)的临床效果及安全性。方法将120例纳入研究的AOPP患者随机分成两组：观察组60例，应用盐酸戊乙奎醚治疗；对照组60例，应用阿托品治疗。比较两组的解毒效果及不良反应发生率。结果观察组的总有效率为93.33%，对照组为80.00%，观察组的疗效明显优于对照组(P<0.05)；观察组的M样症状持续时间为(1.70±0.45)h、N样症状持续时间为(6.38±2.09)h和中枢神经系统症状持续时间(12.50±3.22)h，均显著短于对照组的(2.31±0.52)、(10.25±4.88)、(18.37±3.16)h(P<0.05)；观察组患者所需的意识障碍恢复时间为(23.46±11.30)h、ChE活性恢复时间为(46.81±13.27)h、住院天数为(7.03±2.85)d，均显著短于对照组的(40.58±12.35)h、(63.50±18.94)h、(11.52±3.06)d(P<0.05)；观察组出现心动过速、躁动、视力模糊、尿潴留等不良反应发生率均明显低于对照组(P<0.05)。结论盐酸戊乙奎醚治疗AOPP比阿托品更安全、有效。