益赛普治疗强直性脊柱炎的临床疗效观察

摘要

Objective To observe effects of Etanercept on treating patients with ankylosing spondylitis.Methods Forty-five cases ankylosing spondylitis patients were divided into 2 groups according to resourceful principle.The patients in the control group were given NSAIDS,methotrexate,sulfasalazine,and expectant treatment;the treatment group was given Etanercept 25mg/d plus,beside the medicine used in the control group.Course of treatment was mouths.BASDAI,BASFI,duration of morning stiffness,total body pain and spinal pand, chest expansion,finger to floor distance, occiput to wall distance, Schobers test,Hp and CRP were recorded.Results After6 mouths,all patients had the improvement of symptoms with different degrees.Conclusion Our data indicated that Etanercept treating ankylosing spondylitis has a significant effects.%目的 观察益赛普治疗强直性脊柱炎(AS)的临床疗效.方法 符合AS诊断标准并处于活动期的患者45例采用完全随机设计方法分为治疗组和时照组,时照组22例给予传统治疗药物及对症治疗,疗程半年;治疗组23例在对照组治疗方案的基础上,前2个月给予益赛普,25 mg/次,2次/周.治疗前、后主要观察指标包括活动性指数、功能性指数,晨僵时间、全身和脊柱疼痛程度等,次要观察指标包括扩胸度、枕壁距、Schober试验,血沉、C-反应蛋白及用药安全情况等.结果 治疗组除2例经济困难未坚持治疗、1例出现下呼吸道感染而停止治疗外,余20例患者治疗半年后,多个主要观察指标中均有不同程度的改进,脊柱疼痛、晨僵时间均有明显的改善与好转,且疗效优于对照组(P＜0.05),总有效率90.O%.结论 对于患有活动性强直性脊柱炎患者,在传统治疗药物基础上加用益赛普,能迅速减轻AS的症状和体征,并可改善AS患者的功能、活动范围和生活质量.