急性脑梗死血清Fractalkine浓度变化分析的临床价值

摘要

目的 分析急性脑梗死血清Fractalkine(FKN)浓度的动态变化并探讨其临床意义.方法 收集发病3 d内急性脑梗死患者45例,分别按梗死体积、梗死部位及预后评估分组.以双抗体夹心酶联免疫吸附试验(ELISA)分别测定1～3 d、7 d、14 d和28 d的血清FKN浓度,与健康体检者20例(对照组)比较,分析血清FKN浓度与脑梗死体积、梗死部位、3个月日常生活能力的关系.结果 脑梗死患者各时点的血清FKN浓度均高于对照组(P＜0.01或P＜0.05),并于病后7 d达高峰值;血清FKN浓度在大梗死组、皮层及伴皮层下梗死组高于其他组;依赖组各时点血清FKN浓度均高于独立组.结论 FKN可作为脑缺血炎症损伤的血清标志物,急性脑梗死患者的血清FKN浓度与脑梗死灶的体积、部位及患者的预后相关,可作为观察疗效和判断预后的重要参考指标.%Objective To analyze the significance of serum Fractalkine (FKN) level change in acute cerebral infarction.Methods Forty-five acute ischemic stroke patients were enrolled.Double antibody sandwich EUSA was used to determine serum FKN level at 1～3、7、14 and 28 days after onset.Relation between the serum FKN levels and volume and position of cerebral infarction focus.meanwhile the score of 3 months'quality of life were analyzed.Results Serum FKN levels at different time points in cerebral infaretion group were higher than control group(P＜0.05).FKN reached peak level 7 days after onset.Serum FKN level was significantly higher in large volume infaretion and cortex and concomitant subcortex than other subtypes.Conclusion FKN could be a serum marker for ischemic inflammatory cerebral injury.Serum FKN level in patients with acute cerebral infarction was related to the volume and location of cerebral infarction focus and prognosis of patients.Serum FKN level was an important index for observation of curative effects and prognosis.