Objective To study the clinical characteristics of dermatomyositis compliacted with interstitial lung disease. Methods The patient's clinical symptoms and the laboratory inspection results were analyzed. Results The incidence of dermatomyositis complicated with interstitial lung disease was 25%. The rate of intersti-tial lung disease complicated with myalgia, fever, joint pain was 63.33% (19 cases) , 63.3% (19 cases), 53.3% (16 cases), respectively. Interstitial lung disease-free group included 30 cases (33.3%), 16 cases (17.8% ), 23 cases (25.6%) respectively. Positive rate of anti-jo-1 antibody and patients combined with interstitial lung disease increased the ratio of ESR were 7/30 (23.3%) and 24/30 (80.0%), while those in patients without interstitial lung disease were 0/90 (0) and 45/90 (50.0 % ). Conclusion There's a higher incidence for dermatomyositis pa-tients complicated with interstitial lung disease. Combination of interstitial lung disease shoule be of considered when myalgia, arthralgia and fever occurrs, anti-Jo-1 antibody appears positive and erythrocyte sedimentation rate increases.%目的 探讨皮肌炎合并肺间质病变的临床特点.方法 对比分析皮肌炎伴肺间质病变组(30例)和无肺问质病变组(90例)患者临床症状和实验室检查的结果.结果 皮肌炎合并肺间质病变发病率为25%.合并肺间质病变组中肌痛、发热、关节痛的比例分别是19例(63.3%)、19例(63.3%)、16例(53.3%),无肺间质病变组分别是30例(33.3%)、16例(17.8%)、23例(25.6%),2组比较,差异有统计学意义(P<0.01).合并肺问质病变者抗Jo-1抗体阳性率和红细胞沉降率升高比例分别为7/30(23.3%)、24/30(80.0%).无肺间质病变组分别为0.45/90(50.0%),2组差异有统计学意义(P<0.0l或P<0.05).结论 皮肌炎患者的肺间质病变发生率高,对皮肌炎患者出现肌痛、关节痛、发热等症状,同时抗Jo-1抗体阳性、红细胞沉降率升高时,应警惕合并肺间质病变.
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