复方丹参注射液对阿司匹林抵抗影响的临床研究

摘要

Objective To investigate the effects of the compound Danshen injection and combined with aspirin on platelet aggregation ratio in the patients with aspirin resistance. Methods A total of 52 patients with aspirin resistance and semiresistance were screened for the observation and were randomly assigned to two groups. The first group was administered intravenously with the compound Danshen combined with aspirin, the other group was treated intravenously with compound Danshen only. Two weeks later, all were retested the platelet aggregation ratio. Results The platelet aggregation ratio induced by ADP and AA was (73.8 ±3.9)%, (68.6±3.7)%, (12.7±2.2)% , (18.5 ±2. 3)% ; the platelet aggregation ratio of patients treated with compound Danshen injection and combined with aspirin was (74.2 ±3.8)%, (61.3 ±4.2)%, (23. 1 ±2.6)%, (12.7 ±2.2)%. Both of them had a significantly decrease in various indexes (P <0.05 or P <0.01) ; moreover, the platelet aggregation ratio of patients treated with compound Danshen injection and combined with aspirin has a lower level than that of patients treated with compound Danshen only (P <0. 05 ) . Conclusions Both compound Danshen injection alone and combination with aspirin therapy may reduce platelet aggregation in patients with aspirin resistance.%目的 探讨复方丹参注射液单用及联合阿司匹林对阿司匹林抵抗(AR)患者血小板聚集率的影响.方法 筛选出AR及阿司匹林半抵抗(ASR)患者共52例,完全随机分为2组,单用复方丹参注射液组和阿司匹林+复方丹参注射液组.干预2周后复查血小板聚集率.结果 单用复方丹参注射液组干预前后二磷酸腺苷(ADP)和花生四烯酸(AA)诱导的血小板聚集率分别为(73.8±3.9)%、(68.6±3.7)%、(22.8±2.4)%、(18.5±2.3)%;阿司匹林+复方丹参注射液组分别为(74.2±3.8)%、(61.3±4.2)%、(23.1±2.6)%、(12.7±2.2)%.2组干预后各指标均较干预前有下降,差异有统计学意义(P＜0.05或P＜0.01);阿司匹林+复方丹参注射液组干预后各指标较单用复方丹参注射液组下降,差异亦有统计学意义(P＜0.05).结论 复方丹参注射液单用及联合阿司匹林治疗均可降低AR患者血小板聚集率,但联合应用效果更佳.