B7-H4基因在直肠癌组织的表达及其临床意义

摘要

Objective To explore the expression of B7-H4 in rectal carcinoma and the relationship between its expression and the clinicopathological features. Methods The expression of B7-H4 was detected by immunohistochemistry in 65 patients with rectal carcinomas.Results The positive rate of B7-H4 in cases of rectal carcinomas was 78.5％ (51/65),which was apparently higher than that of normal rectal mucosa epitheliums(P ＜0.05 ).The expression of B7-H4 in patients with rectal carcinomas was closely correlated with stage and lymph node metastasis,but was irrelevant to sex,age and tumor size.The mean survival time in patients with positive expression of B7-H4 was significantly shorter than that of cases with negative expression.Conclusion The overexpression of B7-H4 might be involved in the onset and progression of rectal carcinoma and an be a reference index of poor prognosis in rectal carcinoma.%目的 研究B7-H4基因在直肠癌组织中的表达及其临床意义.方法 采用免疫组织化学SP法检测B7-H4基因分子在65例直肠癌组织中的表达水平.结果 B7-H4基因在直肠癌组织中表达阳性率为78.5％(51/65)；B7-H4基因的阳性表达与直肠癌患者的性别、年龄、肿瘤大小无关(P＞0.05),而与肿瘤分期和有无淋巴结转移相关(P＜0.05)；BT-H4基因阳性表达的直肠癌患者平均生存时间明显短于阴性表达患者[(36±7)个月比(48±9)个月,P＜0.05].结论 B7-H4基因在直肠癌组织的过表达,可能为直肠癌新的具有诊断价值的肿瘤标志物,可作为直肠癌患者预后不良的参考指标.