胸部放疗及放疗序贯多西他赛治疗老年局部晚期非小细胞肺癌的效果观察

摘要

目的 评价胸部放疗序贯多西他赛化疗治疗老年局部晚期肺癌的效果.方法 收集2009年7月至2011年10月76例老年局部晚期非小细胞肺癌患者的病历资料进行回顾性分析,根据治疗方案不同分为放化疗组(37例)和放疗组(39例).放疗组采用适形调强放疗,60 Gy/30 f,放化疗组在放疗组同样方法的放疗结束后序贯多西他赛单药化疗4个周期.结果 治疗后6个月时,放疗组和放化疗组近期总有效率分别为59.0％ (23/39)和51.4％(19/37),组间差异无统计学意义(x2=0.053,P=0.819).放化疗组及放疗组的中位疾病进展时间分别为8.8及7.0个月,组间差异有统计学意义(x2=6.171,P=0.013);放化疗组及放疗组中位生存期分别为15.4及14.8个月,组间差异无统计学意义(x2=0.046,P=0.829).不良反应总体可耐受.结论 适形调强放疗序贯多西他赛化疗治疗老年局部晚期肺癌可延长疾病进展时间,但总生存未见明显改善,不良反应易于耐受.%Objective To study the efficacy and toxicity of thoracic radiotherapy alone and sradiotherapy with docetaxel for elderly patients with local advanced non-small cell lung cancer.Methods Seventy-six patients pathologically diagnosed of non-small cell lung cancer (NSCLC)were arranged into two groups randomly.One group received thoracic radiotherapy of 60 Gy which was divided into 30 fractions ; another received thoracic radiotherapy and sequential docetaxel chemotherapy for four cycles.Results Overall response rate was 59.0％ (23/39),51.4％ (19/37) respectively in radiotherapy group and radiochemotherapy group(x2 =0.053,P =0.819),no difference was observed between radiochemotherapy group and radiotherapy group.There was a significant prolong in progression free time which was 7.0 months and 8.8 months respectively(x2 =6.171,P =0.013),but no difference of overall survival was observed between two groups(x2 =0.046,P =0.829).Hematological toxicity occurred more in sequential chemoraditherapy groups.Conclusions Thoratic radiotherapy with docetaxel improve progression free time but not overall survival time.Its adverse effects are tolerable.