丹参酮ⅡA磺酸钠注射液联合银杏达莫注射液治疗腔隙性脑梗死的效果分析

摘要

目的 探讨丹参酮ⅡA磺酸钠注射液联合银杏达莫注射液治疗腔隙性脑梗死的效果.方法 选取2012年6月至2014年12月湖北医药学院附属东风医院收治的腔隙性脑梗死患者90例,根据随机抽签法分为观察组与对照组,各45例.2组均给予基础治疗,在此基础上对照组给予银杏达莫注射液20 ml+0.9％氯化钠溶液250 ml,静脉滴注,1次/d治疗;观察组在对照组基础上给予丹参酮ⅡA磺酸钠注射液60 mg+0.9％氯化钠液注射250 ml,静脉滴注,1次/d治疗,2组疗程均为14 d.比较2组总有效率及治疗前后红细胞聚集指数和纤维蛋白原水平、血细胞比容与全血比黏度.结果 观察组总有效率高于对照组,差异有统计学意义[95.6％ (43/45)比80.0％(36/45),x2=8.244,P＜0.05].2组治疗后红细胞聚集指数、纤维蛋白原水平、血细胞比容、全血比黏度均较治疗前下降,差异有统计学意义[对照组:(1.6±0.6)比(2.0±0.3),(4.6±1.1)g/L比(6.4±1.3)g/L,(43 ±5)％比(47±5)％,(5.4±0.5) mPa/s比(5.9 ±0.6)mPa/s;观察组:(1.3±0.4)比(2.0±0.4),(3.5±1.1)g/L比(6.4±1.2) g/L,(38±5)％比(47±5)％,(4.6 ±0.4) mPa/s比(6.0 ±0.4) mPa/s,P＜0.05],且观察组低于对照组,差异有统计学意义(P＜0.05).2组不良反应发生率差异无统计学意义(x2 =0.067,P＜0.05).结论 丹参酮ⅡA磺酸钠注射液联合银杏达莫注射液治疗腔隙性脑梗死能有效改善患者的血细胞与血液凝聚状况,从而提高治疗效果,且安全性良好.%Objective To explore the effect of Danshen ⅡA sodium injection combined with Yinxingdamo in treating lacunar infarction.Methods Totally 90 patients with lacunar infarction From June 2012 to December 2014 were randomly divided into observation group and control group (45 cases in each group).Two groups were both given basical treatment;control group were additionally intravenously dripped with Yinxingdamo (20 ml added into 250 ml 0.9％ sodium chloride solution, 1 time/d), observation group were intravenously dripped with Danshen ⅡA sodium injection (60 mg added into 250 ml 0.9％ sodium chloride, 1 time/d) combined with Yinxingdamo (the dose was as above).The treatment was lasted for 14 days.The total effective rate after treatment, the erythrocyte aggregation index, fibrinogen, blood cell hematocrit and whole blood viscosity before and after treatment were compared between groups.Results The total effective rate in observation group was significantly higher than that in control group [95.6％ (43/45) vs 80.0％ (36/45)] (x2 =8.244, P ＜ 0.05).After treatment, the erythrocyte aggregation index, fibrinogen, blood cell hematocrit and whole blood viscosity were all significantly decreased compared with those before treatment in control group [(1.6 ± 0.6) vs (2.0 ± 0.3), (4.6± 1.1) g/L vs (6.4 ± 1.3) g/L, (43 ±5)％ vs (47 ±5)％, (5.4±0.5) mPa/s vs (5.9 ±0.6) mPa/s] and observation group [(1.3 ± 0.4) vs (2.0 ± 0.4), (3.5 ± 1.1) g/L vs (6.4 ± 1.2) g/L, (38 ± 5) ％ vs (47 ± 5) ％, (4.6 ± 0.4) mPa/s vs (6.0 ± 0.4) mPa/s] (P ＜ 0.05);above indicators in observation group were significantly lower than those in control group (P ＜ 0.05).The incidence of adverse reaction were not significantly differently between groups (x2 =0.067, P ＜ 0.05).Conclusion Danshen Ⅱ A sodium injection combined Yinxingdamo can effectively improve the coagulation condition of blood in patient with lacunar infarction, with good safety.