微小RNA-135b在结直肠癌发生发展及治疗中的作用研究进展

摘要

Colorectal cancer has a mtultigenic and multistep pathogenic process.Genic mutations of adenomatous polyposis coli,phosphoinositide-3-kinases,sarcoma gene and P53 mediated by microRNA-135b participate in the pathogenesis and development of colorectal cancer.MicroRNA-135b is involved in multiple signals of gene activity and transcription.Inhibition on microR-135b expression may be a novel anticancer approach.Detection of microRNA-135b in blood and fecal specimen can be a new method for early screening of colorectal cancer.%结直肠癌的发生是一个多基因、多步骤的过程.许多已知基因(结肠腺瘤样息肉基因、磷脂酰肌醇-3-激酶基因、肉瘤基因、P53基因等)的突变都是通过微小RNA-135b(miR-135b)起作用.miR-135b能够通过调控基因的活性,参与许多基因的转录.抑制miR-135b的表达可以同时阻断多个致癌基因的突变,有望成为不引起耐药的抗癌新途径.在血液样本及粪便中筛查miR-135b,有望成为结直肠癌早期筛查的新方法.