盐酸二甲双胍缓释片与普通片治疗2型糖尿病的有效性和安全性

摘要

目的 比较盐酸二甲双胍缓释片和盐酸二甲双胍普通片治疗2型糖尿病的有效性和安全性.方法 选取2013年1月至2017年1月首都医科大学附属北京安贞医院收治的120例2型糖尿病患者,完全随机分为观察组和对照组,各60例.观察组口服盐酸二甲双胍缓释片1 500 mg/次,1次/d;对照组口服盐酸二甲双胍普通片500 mg/次,3次/d;2组均治疗3个月.通过血糖指标、治疗有效率、不良反应等评估药物作用效果.结果 治疗后观察组和对照组患者空腹血糖、餐后2h血糖、糖化血红蛋白水平均较治疗前明显降低[观察组:(5.30±0.21) mmol/L比(8.21 ±0.43) mmol/L、(6.7±1.0) mmol/L比(11.5±1.3) mmol/L、(6.0±1.2)％比(8.5±1.4)％,对照组:(5.31±0.22) mmol/L比(8.22±0.43) mmol/L、(6.7±1.0)mmol/L比(11.5±1.3) mmol/L、(6.1±1.2)％比(8.5±1.4)％](P＜0.05),但组间比较差异无统计学意义(P＞0.05).观察组总有效率稍高于对照组[93.3％ (56/60)比90.0％ (54/60)],组间差异无统计学意义(P＞0.05).2组患者腹泻、上腹疼痛、恶心、消化不良的发生率比较,差异无统计学意义(P＞0.05).结论 盐酸二甲双胍缓释片和普通片治疗2型糖尿病的有效性和安全性相当,但缓释片每日1次,服用方便,依从性更佳.%Objective To analyze the efficacy and safety of metformin hydrochloride sustained release tablets and common metformin hydrochloride tablets in treatment of type 2 diabetes mellitus.Methods Totally 120 patients with type 2 diabetes mellitus were enrolled from January 2013 to January 2017 in Beijing Anzhen Hospital,Capital Medical University;they were divided into observation group and control group,with 60 cases in each group.The observation group took metformin hydrochloride sustained release tablets 1 500 mg/time,1 time/d;the control group took common metformin hydrochloride tablets 500 mag/time,3 times/d;both groups were treated for 3 months.Blood glucose indexes,clinical efficiency and adverse reactions were analyzed.Results Fasting plasma glucose (FPG),postprandial 2 h plasma glucose (2 h PG) and glycosylated hemoglobin (HbA1 c) after treatment were significantly lower than those before treatment[observation group:(5.30 ± 0.21)mmol/L vs (8.21 ± 0.43)mmol/L,(6.7± 1.0)mmol/L vs (11.5 ±1.3)mmol/L,(6.0 ±1.2)％ vs (8.5 ±1.4)％;control group:(5.31 ± 0.22) mmol/L vs (8.22 ±0.43) mmol/L,(6.7 ± 1.0) mmol/L vs (11.5 ± 1.3) mmol/L,(6.1 ± 1.2)％ vs (8.5 ± 1.4)％] (P ＜0.05);there were no significant differences of FPG,2 h PG and HbA1c between groups(P ＞0.05).The total effective rate in observation group was higher than that in control group[93.3％ (56/60) vs 90.0％ (54/60)] (P ＞ 0.05).There was no significant differences of incidences of diarrhea,epigastric pain,vomiting and indigestion between groups(P ＞0.05).Conclusion Metformin hydrochloride sustained release tablets and common metformin hydrochloride tablets are both safe and effective in treatment of type 2 diabetes.