雷帕霉素免疫抑制和抗肿瘤双重效应的研究进展

摘要

Rapamycin (RAPA) is a kind of macrolide antibiotics. Initially it is widely used in clinical as a potent immunosuppressant, which not only has a significant curative effect on a variety of autoimmune diseases, but also shows a good anti-rejectin in organ transplantation and less side effects .In recent years, it's found RAPA has anti-tumor effect, which is a sort of drugs that owning the dual role of immunosuppressive and antitumor. In this paper, the progress of RAPA in the treatment of common diseases for the dual pharmacological effects is reviewed.%雷帕霉素（RAPA）是一种大环内酯类抗生素，最初RAPA在临床上主要作为一种强力的免疫抑制剂而广泛使用，其对多种自身免疫性疾病有显著疗效，而且在器官移植术后显示出良好的抗排斥反应活性，副作用较小，近年来又发现其具有抗肿瘤作用，是一种具有免疫抑制和抗肿瘤双重作用的药物。本文就雷帕霉素（RAPA）双重药理作用的研究进展作一简要综述。