目的：通过观察奥沙拉嗪、美沙拉嗪和柳氮磺吡啶治疗溃疡性结肠炎的效果，比较三种氨基水杨酸制剂治疗溃疡性结肠炎的安全性和有效性。方法120例2011年1月～2014年1月入院治疗溃疡性结肠炎的患者根据治疗用药不同分为三组，奥沙拉嗪组（n=40）、美沙拉嗪组（n=40）和柳氮磺吡啶组（n=40），三组患者用药疗程均为8周；观察三组患者用药治疗后疗效与不良反应。结果奥沙拉嗪组、美沙拉嗪组和柳氮磺吡啶组患者治疗后总有效率分别为77.5%、75.0%和92.5%，柳氮磺吡啶组总有效率（92.5%）显著优于美沙拉嗪组（77.5%）和奥沙拉嗪组（75.0%）（P均＜0.05）。三组不良反应发生率分别为7.5%、7.5%和12.5%，治疗过程中予以对症处理后症状缓解且对治疗无影响。结论柳氮磺吡啶治疗溃疡性结肠炎较美沙拉嗪和奥沙拉嗪疗效更好，不良反应稍高，但对症处理后即可缓解。%Objective To observe the effect of Olsalazine and Mesalazin and Salazosulfapyridine in treatment of ulcerative colitis, and compare the effect and safety between three amino acid preparations. Methods 120 patients with ulcerative colitis in our hospital from January 2011 to January 2014 were divided in to Olsalazine group (n=40) and Mesalazin group (n=40) and Salazosulfapyridine group (n=40) according to different drugs. The course of the treatment of three groups was all 8 weeks and the effect and adverse reaction of three groups were observed. Results the effective rate of Olsalazine group and Mesalazin group and Salazosulfapyridine group after treatment was 77.5%、75.0% and 92.5% respectively, the overall response rate of Salazosulfapyridine group (92.5%) was significant higher than Olsalazine group (77.5%) and Mesalazin group (75.0%),(P<0.05). the adverse reaction rate of three group was 7.5%、7.5% and 12.5% respectively, and symptom relief after symptomatic treatment and no influence to treatment. Conclusion the effect of Salazosulfapyridine in treatment of ulcerative colitis is better than Olsalazine and Mesalazin, all though the adverse reaction rate is a little higher, symptom will relief after symptomatic treatment.
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