目的：探讨孕早期、孕中期及孕晚期孕妇尿碘水平与甲状腺功能的关系。方法采用单纯随机抽样法抽取本地区孕妇405例进行调查，孕早期136例，孕中期141例，孕晚期128例，按甲状腺功能是否正常分为甲状腺功能正常组383例，甲状腺功能异常组22例。结果孕早期、孕中期甲状腺功能正常率明显高于孕晚期，甲状腺功能异常率低于孕晚期，差异有统计学意义（P＜0.05），甲状腺功能正常组孕早期尿碘分级＜100μg/L妇女比例明显低于甲状腺功能异常组孕早期妇女，尿碘分级为100～300μg/L妇女比例明显高于甲状腺异常组孕早期妇女，差异有统计学意义（P＜0.05）。结论尿碘监测对孕早期的孕妇具有重要的意义，建议对尿碘分级＜100μg/L或100～300μg/L的孕妇进行甲状腺功能筛查。%Objective To investigate the relationship between maternal urinary iodine levels and thyroid function at early pregnancy, second trimester and third trimester. Methods We used the simple random sampling method to investigate 405 cases of pregnant women, of which 136 cases of early pregnancy, 141 cases of second trimester, 128 cases of third trimester, divided 383 cases of normal thyroid function group, 22 cases of thyroid dysfunction according to whether it was normal thyroid function. Results The normal thyroid function rate at early pregnancy, second trimester were significantly higher than at third trimester, thyroid dysfunction was lower than at third trimester, the difference was statistically significant(P<0.05), the proportion of urine iodine grading <100μg/L of women in normal thyroid function group at early pregnancy was significantly lower than the proportion of abnormal thyroid function of women at early pregnancy, the proportion of urinary iodine rating with 100-300μg/L of women was significantly higher than the proportion of women in thyroid abnormalities group at early pregnancy, the difference was statistically significant(P<0.05). Conclusion Urinary iodine monitoring for pregnant women at early pregnancy has important significance, urinary iodine rating < 100μg/L or with 100-300μg/L of pregnant women should be proposed to screen for thyroid function.
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