Objecitve To investigates the change of IL-6, IL-12 and IL-33 in serum of patients with hepatitis C and its clinical significance. Methods The expression of IL-6, IL-12 and IL-33 in serum were detected in 30 cases of patients with hepatitis C, 30 cases of hepatitis C virus carriers and 30 cases of healthy control group by ELISA. Results Compared with the hepatitis C virus carriers and healthy control group, the expression level of IL-6, IL-12 and IL-33 in the serum of patients with hepatitis C was significantly elevated(P<0.01), and the expression level of IL-6, IL-12 and IL-33 in the serum of hepatitis C patients were significantly higher than that of hepatitis C virus carriers(P < 0.01); The content of IL-6, IL-12 and IL-33 in the serum of patients with hepatitis C were decreased significantly after treatment(P<0.01). Conclusion IL-6, IL-12 and IL-33-mediated immune responses involved in the pathogenesis of hepatitis C infection, and have certain clinical value in the pathogenesis of HCV infection.%目的：探讨丙型肝炎患者血清中IL-6、IL-12及IL-33含量的变化及其临床意义。方法ELISA法检测30例丙型肝炎患者、30例丙型肝炎病毒携带者及30例健康对照者血清中IL-6、IL-12及IL-33的表达水平。结果相比丙型肝炎病毒携带者及健康对照者，丙型肝炎患者血清中IL-6、IL-12及IL-33的表达水平显著升高（P＜0.01），且丙型肝炎患者血清中IL-6、IL-12及IL-33的含量显著高于丙型肝炎病毒携带者（P＜0.01）；经治疗后丙型肝炎患者血清中IL-6、IL-12及IL-33的含量显著降低（P＜0.01）。结论IL-6、IL-12及IL-33介导的免疫应答参与了丙型肝炎的发病，在丙型肝炎病毒感染的致病机制中有一定的临床价值。
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