美罗培南治疗细菌性脑膜炎疗效观察

摘要

Objective To observe the clinical effects of meropenem in the treatment of bacterial meningitis. Methods 56 adult patients with bacterial meningitis who were admitted to our hospital from June 2010 to June 2013 were selected and randomLy assigned to two groups, with 28 patients in each group. The control group received intravenous drip of ceftriaxone sodium, while the observation group received intravenous drip of meropenem based on ceftriaxone sodium. The curative effects were compared between the two groups. Results Total effective rate for one week of treatment in the observation group was 67.9%, and 92.9%for two weeks, which were significantly higher than those of 21.4%and 53.6%respectively (P<0.01);bacteria eliminating rate in the observation group was 92.9%, significantly higher than that of 67.2%in the control group (P<0.01). Conclusion A proper use of meropenem treatment based on the results of drug sensitive test in early stages helps improve the curative effects of bacterial meningitis.%目的：观察美罗培南治疗细菌性脑膜炎的临床疗效。方法选取2010年6月～2013年6月我院确诊为细菌性脑膜炎的成人患者56例，随机分为两组，每组28例，对照组用头孢曲松钠静脉滴注；观察组在对照组的基础上加用美罗培南静脉滴注治疗，对比两组疗效。结果观察组治疗1周总有效率为67.9%、2周为92.9%，显著高于对照组的21.4%、53.6%（P＜0.01）；观察组细菌清除率（92.9%）显著高于对照组（67.2%）（P＜0.01）。结论早期根据药敏试验结果合理使用美罗培南治疗方案能有助于提高细菌性脑膜炎的治疗效果。