目的：对福建建阳小湖采集的鱼腥草4个不同部位（根、茎、叶、果实）挥发性成分进行分析、比较，为选择适宜的用药部位，改进鱼腥草相关制剂制备工艺、提高质量水平提供研究思路和方法学参考。方法收集指定产地鱼腥草的不同部位，采用顶空固相微萃取-气相色谱-质谱（HS-SPME-GC-MS）对其所含的挥发性成分分别提取、分离、鉴定，采用归一化法测定成分的相对含量，并进行比对。结果鱼腥草药材不同部位所含挥发性成分的种类和相对含量均存在较大差异，其中药效成分鱼腥草素、甲基正壬酮在果实中含量最高，其他部位含量则相对较低。结论鱼腥草不同部位挥发性成分的差异表明规范中药材入药部位和采收季节的重要性，在中药制剂生产过程中须严格把关，确保临床疗效和用药安全性。%Objective To perform qualitative and quantitative analysis on the volatile components in different parts(root,stem,leaf and flower)of Herba Houttuyniae sourced from Xiaohu Jianyang.To provides research ideas and methods for choosing appropriate medicinal parts and improving the preparation process and quality level. Methods The different parts of Herba Houttuyniae sourced from Xiaohu Jianyang were collected.The volatile component were analyzed by HS-SPME-GC-MS,and the relative percentage content of each component was calculate with peak area normalization method.Results The volatile components in Herba Houttuyniae had remarkable differences because of the different parts. As the effective components in Herba Houttuyniae, it was indicated that the content of both acetaldehyde and methyl-n-nonyl-ketone were the highest in fruits and relatively lower in other parts of Herba Houttuyniae.ConclusionStandardized medicinal part and collecting seasons of traditional Chinese medicine was important because of the volatile constituents difference from different parts of Herba Houttuyniae.It was necessary to inspect and check in Preparation of Chinese medicine.The clinical curative effect and medication security must be guaranteed.
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