脑梗死合并糖尿病患者血糖控制水平对阿司匹林抵抗的影响

摘要

Objective To investigate the blood glucose level of aspirin resistance with cerebral infarction combined diabetes.Methods 80 cases were choosed,the observation group were used the normal range of blood glucose to control and maintain stable blood sugar and the control,control group were hold blood sugar between 6.1~13.3mmol/L, both groups were oralled aspirin,then platelet aggregation,platelet-associated changes in their understanding indicators,occurrence of aspirin and aspirin-sensitive resistance ratio were compared. Results Hyperglycemia in patients with 5μmol/L and 1μmol/L of adenosine diphosphate-induced platelet aggregation were significantly larger than control group(P<0.05),elevated blood glucose in patients with PLT count were less than normal group (P<0.05),PLT average volume,PLT distribution width and hematocrit were lower than control group(P<0.05),the proportion of platelet resistance to elevated blood glucose was significantly higher than control group,platelet sensitivity was lower than control group(P<0.05).Conclusion Patients with cerebral infarction combined diabetes to maintain normal blood sugar stable has a very positive meaning to reduce aspirin resistance.%目的：探讨脑梗死合并糖尿病患者血糖控制水平对阿司匹林抵抗的影响。方法选择患者80例，观察组将血糖控制在正常范围，并保持血糖平稳，对照组血糖控制在6.1～13.3mmol/L之间，两组均口服拜阿司匹林，治疗比较两组血小板聚集功能，了解其血小板相关变化指标，统计发生阿司匹林抵抗和阿司匹林敏感的比率。结果对照组患者5μmol/L和1μmol/L二磷酸腺苷诱导血小板最大聚集率均显著大于观察组（P＜0.05），对照组患者PLT计数少于观察组（P＜0.05），PLT平均体积、PLT压积和PLT分布宽度低于观察组（P＜0.05），对照组血小板抵抗的比例显著高于观察组，血小板敏感的比例显著低于观察组（P＜0.05）。结论对于脑梗死合并糖尿病患者，维持血糖正常且稳定，在减少阿司匹林抵抗方面具有十分积极的意义。