Objective To study the correlation of risperidone-induced changes on serum thyroxin with changes on blood glucose and lipid. Methods 35 schizophrenia patients were given risperidone 1-6mg/d for 8 weeks. Triiodothyronine (T3), thyroxin (T4), free triiodothyronine (FT3), free thyroxin (FT4), glucose (GLU) and triglyceride (TG) of all patients were measured before and after treatment. Before and after treatment, T3, T4, FT3, FT4, GLU and TG were compared respectively (t test), and the correlation of T3, T4, FT3, FT4 changs with GLU and TG changes were analyzed (Pearson test). Results After 8 weeks treatment, there was no significant difference in T3 compared with pre-treatment. T4, FT4 and GLU were significantly decreased than before treatment(P<0.05, P<0.05, P<0.01);TG were significantly increased (P<0.05). Changes between T4, FT4 and GLU were positively correlated (P<0.01, and P < 0.05). Changes between T3, FT3 and GLU were not related. And changes between T3, FT3, T4, FT4 and GLU had no correlation. Conclusion Risperidone could reduce thyroid, glucose and elevated blood lipid. There were positive correlations between the decrease of thyroid and the reduce blood glucose.%目的：研究利培酮致血清甲状腺激素水平改变与血糖、血脂水平改变之间的相关性。方法给予35例精神分裂患者利培酮8周治疗，治疗前后分别测定血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、血糖（GLU）和甘油三酯（TG）水平。分别对比治疗前后各因素水平的变化情况（t检验），并对因素水平改变差值之间进行相关性分析（Pearson检验）。结果与治疗前比，治疗后血清T3水平无统计学差异，T4、FT4水平显著降低（P＜0.05）；GLU水平和TG水平分别有极显著性降低和升高（P＜0.01）。T4、FT4变化与GLU变化呈正相关，有统计学意义（P＜0.01、P＜0.05）；T3、FT3变化与GLU变化均无相关性。T3、FT3、T4和FT4变化与TG变化均无相关性。结论利培酮可以降低甲状腺激素、血糖水平，升高血脂水平，并且降低甲状腺激素与降低血糖之间有相关性。
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