2013年某医院全年细菌耐药与抗菌药物临床应用预警分析

摘要

Objective To give a early warning to the clinical application of antibacterial drugs by analyzing the date of the drug resistance of bacteria and antibacterial drug use of the hospital,in order to provide technical support for the clinical rational use of antibacterial drugs. Methods Pathogen infection of hospitalized patients in 2013 was obtained from the clinical laboratory.The results of bacterial culture and drug susceptibility were analyzed, and the top five bacteria(e.coli,klebsiella pneumoniae,pseudomonas aeruginosa,staphylococcus aureus and acinetobacter baumannii)were selected to perform statistical analysis by WHONET software. Results The early warnings of the top five bacteria were provided by the drug resistance rate of 30%-40%,41%-50%,41%-75%and>75%. Conclusion The drug resistance of bacteria and the use of antibacterial drug are related.Rational use of antimicrobial agents referencing drug susceptibility test results based on bacterial drug resistance monitoring and avoiding the generation of drug-resistant bacteria,it is the key to reduce hospital infection.%目的：通过对医院细菌耐药和抗菌药物使用资料的统计，对抗菌药物临床应用给予预警，从而为临床合理使用抗菌药物提供技术支持。方法从检验科获取2013年全年的住院患者病原菌感染情况，分析全院细菌培养和药敏结果，选取全院排名前五的细菌（大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌、鲍曼不动杆菌）进行WHONET软件统计分析。结果排名前五的细菌耐药率按30%～40%、41%～50%、51%～75%、＞75%进行抗菌药物预警。结论细菌耐药和抗药物的使用是有相关的，参照药敏试验结果，以细菌耐药监测为依据，合理使用抗菌药物，避免细菌耐药的产生，减少医院感染的关键。