Objective To research the effects of low-molecular-weight heparin combined with conventional therapy for early onset preeclampsia. Methods 96 patients with early onset preeclampsia, who were in hospital from March 2013 to September 2015, were retrospectively analyzed and divided into the observation group (n=50) and the control group (n=46) according to the treatment method, The observation group was treated by low-molecular-weight heparin plus the routine therapy, while the control group was given routine therapy. The blood pressure, 24 hours urinary protein, Fetal umbilical artery S/D ratio, the perinatal asphyxia and death ,and postpartum haemorrhage amount of all the patients were recorded. Results The blood pressure drop, Fetal umbilical artery S/D ratio, the perinatal asphyxia and death of observation group were significantly higher than those of control group(P < 0.05). There was no significant difference on postpartum haemorrhage amount between two groups (P > 0.05). Conclusion Low-molecular-weight heparin combined with conventional therapy helps lower blood pressure for patient with early onset preeclampsia, and can prolong the pregnancy weeks, improve the pregnancy outcome. It can not increase the risk of bleeding. It is worthy of clinical application.%目的：探讨应用低分子肝素联合常规疗法治疗早发型子痫前期的疗效。方法回顾性分析2013年3月～2015年9月住院治疗的早发型子痫前期孕妇共96例，根据治疗方法分为观察组（n=50）和对照组（n=46），观察组采用低分子肝素联合常规疗法，对照组采用常规疗法治疗，观察两组治疗前后血压下降幅度、24h尿蛋白、胎儿脐动脉S/D比值、围生儿窒息与死亡、产后出血量。结果两组治疗前后血压下降幅度、24h尿蛋白、胎儿脐动脉S/D比值、新生儿出生情况比较，差异有统计学意义（P＜0.05）；两组治疗后产后出血量差异无统计学意义（P＞0.05）。结论低分子肝素联合常规疗法治疗早发型子痫前期有助于降压治疗，能延长孕周，改善妊娠结局，不增加出血危险，值得临床推广应用。
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